Results 31 to 40 of about 3,803 (163)

Paraoxonase 1 and Non-Alcoholic Fatty Liver Disease: A Meta-Analysis

Molecules, 2021
Oxidative stress is involved in the pathophysiology of nonalcoholic fatty liver disease (NAFLD). However, reliable biomarkers of NAFLD in relation to oxidative stress are not available.
Kazuhiko Kotani, Jun Watanabe, Kouichi Miura, Alejandro Gugliucci   +3 more
doaj   +1 more source

Decreased serum arylesterase activity in autism spectrum disorders.

, 2010
The PON1 gene, previously found associated with autism spectrum disorders (ASDs), encodes a serum protein responsible for the detoxification of organophosphates (OPs) and able to exert several enzymatic activities.
Smith, CJ, Brautigam, S, Craig, David W., Redman, M, Persico, Antonio M., Melmed, R, Marsillach, J, Persico, A.M., Lintas, C, Sacco, R, Craig, DW, Gaita, L, Pawlowski, Tracy L., Brautigam, Sarah, Huentelman, MJ, Persico, AM., Manzi, B, CURATOLO, PAOLO, Ober-Reynolds, S, Smith, Christopher J., Redman, Margot, Altieri, Laura, Curatolo, P, Sacco, Roberto, Pawlowski, TL, Lombardi, F, Camps, J, Manzi, Barbara, Lintas, Carla, Ober-Reynolds, Sharman, Ober Reynolds, S, Lombardi, Federica, Gaita, Laura, Altieri, L, Melmed, Raun, Marsillach, Judith, Huentelman, Matthew J., Camps, Jordi   +37 more
core   +1 more source

Preferable stimulation of PON1 arylesterase activity by phosphatidylcholines with unsaturated acyl chains or oxidized acyl chains at sn-2 position [PDF]

, 2006
To examine the effect of phospholipids on PON1 activities, purified PON1 was exposed to phospholipids prior to the determination of arylesterase and paraoxonase activities. Phosphatidylcholines with saturated acyl chains (C10–C16) showed a stimulation of
Sok, Dai-Eun, Nguyen, Su Duy
core   +1 more source

The relationship between serum ferritin levels and serum lipids and HDL function with respect to age and gender [PDF]

The Ukrainian Biochemical Journal, 2016
Elevated serum ferritin (SFer) levels have been associated with chronic diseases such as coronary heart disease and diabetes mellitus type 2. The aim of this study was to examine the relationship between SFer levels and serum lipid parameters, and how ...
Hamit Yasar Ellidag, Esin Eren, Mehmet Akdag, Ozlem Giray, Kemal Kiraz, Necat Yilmaz   +5 more
doaj   +1 more source

Serum Arylesterase, Paraoxonase, and Lactonase Activities and Paraoxonase-1 Concentrations in Morbidly Obese Patients and Their Relationship with Non-Alcoholic Steatohepatitis

Antioxidants, 2023
Paraoxonase-1 (PON1) is an antioxidant enzyme associated with high-density lipoproteins (HDL). Reduced serum PON1 activity is found in diseases marked by oxidative stress and inflammation, but its role in obesity remains unclear.
Helena Castañé, Andrea Jiménez-Franco, Cristian Martínez-Navidad, Cristina Placed-Gallego, Vicente Cambra-Cortés, Adelina-Miruna Perta, Marta París, Daniel del Castillo, Meritxell Arenas, Jordi Camps, Jorge Joven   +10 more
doaj   +1 more source

Metal‐Dependent Effects and Crowding Robustness of Pseudomonas fluorescens Esterase I

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Pseudomonas fluorescens esterase I retains catalytic activity in metal‐rich and crowded environments, despite metal‐specific inhibitory effects. These findings highlight its robustness for biocatalytic applications in complex environments. Industrial biocatalysts are strongly influenced by their physicochemical environment, yet systematic studies on ...
Emmanouil Ntermanakis, Nikoleta Syngelaki, Alexandros Lyratzakis, Renia Fotiadou, Spyridoula Charova, Ioannis V. Pavlidis, Angeliki Giannouli   +6 more
wiley   +1 more source

Unlocking Lactonase Enzymes as Biocatalysts for the Deracemisation of Chiral γ‐Thiolactones

Angewandte Chemie, Volume 137, Issue 29, July 14, 2025.
The application of lactonase enzymes as biocatalysts still remains underexplored. This study discloses the biocatalytic activity of two lactonases in the deracemisation of chiral C3‐substituted‐γ‐thiolactones. The biocatalyst GcL catalyses the enzymatic kinetic resolution (EKR) of C3‐amide‐thiolactones, while the rationally engineered biocatalyst N9 ...
Jingyue Wu, Michele Crotti, Ivan Bassanini, Mahdi Hassankalhori, Erica Elisa Ferrandi, Ferran Sancho, Daniela Monti, Daniele Castagnolo   +7 more
wiley   +2 more sources

Mitochondrial‐Haplotype Influences Plasma Metabolome, Lipidome, and Proteome in a Sex Specific Manner in the Genetically Heterogenous OKC‐HETB/W Rat

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
Multi‐omics profiling uncovers the effect of sex and mitochondrial‐haplotype on molecular fingerprints of aging in plasma. ABSTRACT The effect of mitochondrial‐haplotype (mt‐haplotype) on aging was studied using a unique rat model (OKC‐HETB/W), which has a heterogenous nuclear background combined with mitochondria from either Brown Norway (B‐haplotype)
Hoang Van M. Nguyen, Finterly Hu, Evaniya Shakya, Chloe Fender, Kenneth Lee, Jason Schindler, Manuel Garcia‐Jaramillo, Nagib Ahsan, Janet C. Siebert, Sarah J. Borengasser, Norman G. Hord, Michael B. Stout, Steven Austad, Arlan Richardson   +13 more
wiley   +1 more source

Comparison of the effects of high-dose atorvastatin and high-dose rosuvastatin on oxidative stress in patients with acute myocardial infarction: A pilot study

Türk Kardiyoloji Derneği Arşivi, 2017
Objective: Oxidative stress is increased in patients with acute myocardial infarction (AMI). Statins reduce oxidative stress independent of their effect in reducing low-density lipoprotein cholesterol (LDL-C).
Celal Kilit, Fatma Emel Koçak, Türkan Paşalı Kilit   +2 more
doaj   +1 more source

Protein glycosylation in lung cancer from a mass spectrometry perspective

Mass Spectrometry Reviews, Volume 45, Issue 3, Page 455-475, May/June 2026.
ABSTRACT Lung cancer is a severe disease for which better diagnostic and therapeutic approaches are urgently needed. Increasing evidence implies that aberrant protein glycosylation plays a crucial role in the pathogenesis and progression of lung cancer.
Mirjam Balbisi, Simon Sugár, Lilla Turiák   +2 more
wiley   +1 more source