Results 11 to 20 of about 4,209 (153)
Journal of Diabetes Research, 2020 Background. Paraoxonase 1 (PON1) is a calcium-dependent multifunctional enzyme that binds to high-density lipoproteins. The physiological function of PON1 is related to its lactonase activity.
Mi Zhou +6 more
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Molecules, 2022 The lactonase activity of paraoxonase 1 (PON1) has a crucial antiatherogenic function, and also serves as an important biochemical marker in human blood because the aberrant lactonase activity of PON1 is a key indicator for a number of diverse human ...
Bo-Kai Fang +10 more
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Low Serum Paraoxonase-1 Lactonase and Arylesterase Activities in Obese Children and Adolescents
Romanian Journal of Laboratory Medicine, 2015 Serum paraoxonase-1 (PON1) binds mainly to high density lipoproteins (HDLs) and protects low density lipoproteins (LDLs) against oxidation. While paraoxonase and arylesterase activities are traditionally assayed, lactonase activity, accounting for ...
Sandor Raluca +6 more
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Differential active site loop conformations mediate promiscuous activities in the lactonase SsoPox.
PLoS ONE, 2013 Enzymes are proficient catalysts that enable fast rates of Michaelis-complex formation, the chemical step and products release. These different steps may require different conformational states of the active site that have distinct binding properties ...
Julien Hiblot +3 more
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A novel YtnP lactonase reduces the expression of p. aeruginosa MMA83 quorum sensing andvirulence factors gene expression [PDF]
, 2023 Introduction: Quorum quenching (QQ) isthe enzymatic degradation of cell-to-cellsignaling molecules.In this study, the potential of the novel YtnP lactonase, the quorum quenching enzyme derived from S.maltophilia, to reduce P.
Ćurčić, Jovana +6 more
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Reproductive Biology and Endocrinology, 2023 Background Childbearing in women with advanced maternal age (AMA) has increased the need for artificial reproductive technology (ART). ART and oxidative stress are associated with many pregnancy complications.
Chenyu Jiang +5 more
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Antioxidants, 2023 Paraoxonase-1 (PON1) is an antioxidant enzyme associated with high-density lipoproteins (HDL). Reduced serum PON1 activity is found in diseases marked by oxidative stress and inflammation, but its role in obesity remains unclear.
Helena Castañé +10 more
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Use of Quorum Sensing Inhibition Strategies to Control Microfouling
Marine Drugs, 2021 Interfering with the quorum sensing bacterial communication systems has been proposed as a promising strategy to control bacterial biofilm formation, a key process in biofouling development. Appropriate in vitro biofilm-forming bacteria models are needed
Andrea Muras +3 more
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Reduced Serum PON1 Lactonase Activity Is Associated with Mild Cognitive Impairment and Mixed Dementia. [PDF]
Antioxidants (Basel)High-density lipoprotein (HDL)-associated paraoxonase-1 (PON1) contributes substantially to the antioxidant and anti-inflammatory functions of HDL. Impairment of these protective properties has been associated with Alzheimer’s disease (AD) and other ...
Riccetti R +9 more
europepmc +2 more sources
Expression of paraoxonase 1 in HEK293 cells and its effect on lactonase and arylesterase activity in samples containing human serum and/or prooxidant or antioxidant agents - a preliminary study [PDF]
Acta Poloniae Pharmaceutica, 2023 Expression of recombinant paraoxonase 1 (PON1) in the human embryonic kidney (HEK293F) cell line was evaluated. Two recombinant human PON1 proteins were investigated: PON1-Fc, which has an Fc-tag on its C-terminal, and His-PON1-Fc, which has an Fc-tag on
Anna Bizoń, Agnieszka Piwowar
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