Low Serum Paraoxonase-1 Lactonase and Arylesterase Activities in Obese Children and Adolescents
Romanian Journal of Laboratory Medicine, 2015 Serum paraoxonase-1 (PON1) binds mainly to high density lipoproteins (HDLs) and protects low density lipoproteins (LDLs) against oxidation. While paraoxonase and arylesterase activities are traditionally assayed, lactonase activity, accounting for ...
Sandor Raluca +6 more
doaj +2 more sources
Journal of Diabetes Research, 2020 Background. Paraoxonase 1 (PON1) is a calcium-dependent multifunctional enzyme that binds to high-density lipoproteins. The physiological function of PON1 is related to its lactonase activity.
Mi Zhou +6 more
doaj +2 more sources
Lactonase Specificity Is Key to Quorum Quenching in Pseudomonas aeruginosa [PDF]
Frontiers in Microbiology, 2020 The human opportunistic pathogen Pseudomonas aeruginosa orchestrates the expression of many genes in a cell density-dependent manner by using quorum sensing (QS). Two acyl-homoserine lactones (AHLs) are involved in QS circuits and contribute to the regulation of virulence factors production, biofilm formation, and antimicrobial sensitivity.
Benjamin Rémy +7 more
openaire +5 more sources
Differential active site loop conformations mediate promiscuous activities in the lactonase SsoPox.
PLoS ONE, 2013 Enzymes are proficient catalysts that enable fast rates of Michaelis-complex formation, the chemical step and products release. These different steps may require different conformational states of the active site that have distinct binding properties ...
Julien Hiblot +3 more
doaj +2 more sources
The characterization of a new stabilized lactonase from the endophytic fungi Aspergillus pseudonomiae with anti-bacterial and anti-fungal properties. [PDF]
Protein SciAbstract Microorganisms use diverse small‐molecule signals to coordinate behavior, supporting interspecies and interkingdom communication. These chemical dialogs shape fundamental biological processes and define interactions from cooperation to antagonism.
Ben Tovim D +4 more
europepmc +2 more sources
A novel YtnP lactonase reduces the expression of p. aeruginosa MMA83 quorum sensing andvirulence factors gene expression [PDF]
, 2023 Introduction: Quorum quenching (QQ) isthe enzymatic degradation of cell-to-cellsignaling molecules.In this study, the potential of the novel YtnP lactonase, the quorum quenching enzyme derived from S.maltophilia, to reduce P.
Ćurčić, Jovana +6 more
core +3 more sources
Marked Long-Term Improvement in Lung Function in Melanoma Differentiation-Associated Protein 5 Antibody-Positive Dermatomyositis Patients: Experience of a Single-Center Longitudinal Cohort in North America. [PDF]
Arthritis Care Res (Hoboken)Objective The objective of this study was to describe the longitudinal disease course and pulmonary outcomes of North American patients with melanoma differentiation–associated protein 5 (MDA5) antibody–associated dermatomyositis (DM). Methods Thirty patients with MDA5 antibody–associated DM were identified in a single‐center longitudinal cohort of 352
Cheah JX +8 more
europepmc +2 more sources
The Structure and Function of Paraoxonase-1 and Its Comparison to Paraoxonase-2 and -3
Molecules, 2020 Serum paraoxonase-1 (PON1) is the most studied member of the group of paraoxonases (PONs). This enzyme possesses three enzymatic activities: lactonase, arylesterase, and paraoxonase activity.
Ajda Taler-Verčič +2 more
doaj +1 more source
Human Paraoxonase-2 (PON2): Protein Functions and Modulation
Antioxidants, 2021 PON1, PON2, and PON3 belong to a family of lactone hydrolyzing enzymes endowed with various substrate specificities. Among PONs, PON2 shows the highest hydrolytic activity toward many acyl-homoserine lactones (acyl-HL) involved in bacterial quorum ...
Giuseppe Manco +2 more
doaj +1 more source
Specificity and Enzyme Kinetics of the Quorum-quenching N-Acyl Homoserine Lactone Lactonase (AHL-lactonase) [PDF]
Journal of Biological Chemistry, 2004 N-Acyl homoserine lactone (AHL) quorum-sensing signals are the vital elements of bacterial quorum-sensing systems, which regulate diverse biological functions, including virulence. The AHL-lactonase, a quorumquenching enzyme encoded by aiiA from Bacillus sp., inactivates AHLs by hydrolyzing the lactone bond to produce corresponding N-acyl homoserines ...
Wang, L.-H. +3 more
openaire +2 more sources