Results 31 to 40 of about 4,426 (184)

A Rhodococcal Transcriptional Regulatory Mechanism Detects the Common Lactone Ring of AHL Quorum-Sensing Signals and Triggers the Quorum-Quenching Response

Frontiers in Microbiology, 2018
The biocontrol agent Rhodococcus erythropolis disrupts virulence of plant and human Gram-negative pathogens by catabolizing their N-acyl-homoserine lactones.
Corinne Barbey, Corinne Barbey, Corinne Barbey, Corinne Barbey, Andrea Chane, Andrea Chane, Jean-François Burini, Jean-François Burini, Olivier Maillot, Olivier Maillot, Annabelle Merieau, Annabelle Merieau, Mathias Gallique, Mathias Gallique, Amélie Beury-Cirou, Amélie Beury-Cirou, Amélie Beury-Cirou, Yoan Konto-Ghiorghi, Yoan Konto-Ghiorghi, Marc Feuilloley, Marc Feuilloley, Virginie Gobert, Virginie Gobert, Virginie Gobert, Xavier Latour, Xavier Latour   +25 more
doaj   +1 more source

Evolution of Resistance to Quorum Quenching in Digital Organisms [PDF]

Artificial Life, 2012
Quorum sensing (QS) is a collective behavior whereby actions of individuals depend on the density of the surrounding population. Bacteria use QS to trigger secretion of digestive enzymes, formation and destruction of biofilms, and, in the case of pathogenic organisms, expression of virulence factors that cause disease. Investigations of mechanisms that
Benjamin E. Beckmann, David B. Knoester, Brian D. Connelly, Christopher M. Waters, Philip K. McKinley   +4 more
openaire   +2 more sources

Structural and Functional Siderophore Remodeling by Enzymatic Delipidation

Angewandte Chemie, EarlyView.
A surprising functional switch in bacterial siderophores was discovered through genome mining and the analysis of environmental and pathogenic Pandoraea species. Pandorachelin B, a lipocyclopeptide that promotes swarming motility, is cleaved by a specialized acylase, yielding a ring‐contracted, homodetic cyclopeptide, pandorachelin A, which exhibits ...
Elena Herzog, Keishi Ishida, Evelyn M. Molloy, Ron Hermenau, Kirstin Scherlach, Christian Hertweck   +5 more
wiley   +2 more sources

Screening of N-Acyl Homoserine Lactone-degrading Bacteria and Evaluation of Their Quorum Quenching Activities

Shipin gongye ke-ji
To study the types of quorum quenching bacteria in soil and their quorum quenching characteristics, the study screened, isolated, and identified quorum quenching strains from soil and assessed their quorum quenching properties, the inhibitory and ...
Xiqian TAN, Xiaoqing WANG, Fangchao CUI, Dangfeng WANG, Xinran LÜ, Xuepeng LI, Jianrong LI   +6 more
doaj   +1 more source

Signal Disruption Leads to Changes in Bacterial Community Population

Frontiers in Microbiology, 2019
The disruption of bacterial signaling (quorum quenching) has been proven to be an innovative approach to influence the behavior of bacteria. In particular, lactonase enzymes that are capable of hydrolyzing the N-acyl homoserine lactone (AHL) molecules ...
Michael Schwab, Michael Schwab, Celine Bergonzi, Celine Bergonzi, Jonathan Sakkos, Christopher Staley, Christopher Staley, Qian Zhang, Qian Zhang, Michael J. Sadowsky, Michael J. Sadowsky, Michael J. Sadowsky, Alptekin Aksan, Alptekin Aksan, Mikael Elias, Mikael Elias   +15 more
doaj   +1 more source

Breaking down bacterial communication: a review of quorum quenching agents

Future Journal of Pharmaceutical Sciences, 2023
Background Bacterial cells communicate via small extracellular molecules that facilitate gene expression which is dependent on cell density and this mechanism is known as Quorum Sensing (QS).
Tresa Boban, Sahaya Nadar, Savita Tauro
doaj   +1 more source

Repression of Virulence in Staphylococcus aureus by 2‐Aminothiol‐Mediated Quorum Quenching

Angewandte Chemie, EarlyView.
Simple analogues of cysteine that can eliminate the native autoinducing peptides (AIPs) of staphylococci extracellularly, before they activate their receptor, and turn off quorum sensing in different Staphylococcus aureus. The elimination of AIPs occurs through a mechanism similar to native chemical ligation (NCL). Further, this strategy showed promise
Bengt H. Gless, Riccardo Milazzo, Martin S. Bojer, Benjamin S. Sereika‐Bejder, Hanne Ingmer, Christian A. Olsen   +5 more
wiley   +2 more sources

Rhodotorula Mucilaginosa, a Quorum Quenching Yeast Exhibiting Lactonase Activity Isolated from a Tropical Shoreline

Sensors, 2014
Two microbial isolates from a Malaysian shoreline were found to be capable of degrading N-acylhomoserine lactones. Both Matrix Assisted Laser Desorption Ionization-Time of Flight-Mass Spectrometry and 18S rDNA phylogenetic analyses confirmed that these ...
Norshazliza Ab Ghani, Joanita Sulaiman, Zahidah Ismail, Xin-Yue Chan, Wai-Fong Yin, Kok-Gan Chan   +5 more
doaj   +1 more source

Quorum-Sensing Regulation of Antimicrobial Resistance in Bacteria

Microorganisms, 2020
Quorum sensing is a cell-to-cell communication system that exists widely in the microbiome and is related to cell density. The high-density colony population can generate a sufficient number of small molecule signals, activate a variety of downstream ...
Xihong Zhao, Zixuan Yu, Tian Ding
doaj   +1 more source

Gardiquimod Nanoemulsion Targets Cutaneous Leishmaniasis Lesions Reducing Systemic Toxicity and Parasite Burden

Advanced Healthcare Materials, EarlyView.
Nanoemulsion delivery of a TLR7 agonist enhances safety and promotes colocalization with Leishmania‐infected macrophages in skin lesions, enabling a ∼2‐log reduction in parasite burden. However, tissue‐level constraints and TLR‐driven regulatory feedback generate a mixed immune response that limits complete parasite clearance.
Carmen Palomino‐Cano, M. Carmen Mera‐Delgado, Esther Moreno, Esther Larrea, Lecnia Aguirre, Jonathan Miguel Zanatta, Sónia Barros‐Carvalho, Iola F. Duarte, Ricardo Silvestre, Juan M. Irache, Javier Carrión, Socorro Espuelas   +11 more
wiley   +1 more source