Results 231 to 240 of about 8,340 (295)

Human IDO2 exhibits unique binding affinities distinct to those of human IDO1

The FEBS Journal, EarlyView.
Although indoleamine 2,3‐dioxygenase 2 (IDO2) is highly homologous to IDO1, it displays markedly lower catalytic activity. We found that IDO2 binds L‐tryptophan (L‐Trp) in a flipped orientation stabilized by the IDO2‐specific residue His143. Replacement of His143 with the IDO1‐equivalent tyrosine restored an IDO1‐like binding mode and increased ...
Shunsuke Nogi, Ayumu Takahashi, So Murakami, Nami Adachi, Tina Fujimoto, Yohta Fukuda, Taku Yamashita, Tsuyoshi Inoue, Hirofumi Tsujino   +8 more
wiley   +1 more source

Metabolic Multimorbidity and Risk of All-Cause and Cause-Specific Mortality: A Retrospective Cohort Study of 123,791 Chinese Adults. [PDF]

Diabetes Metab Syndr Obes
Ran X, Fan Z, Wang N, Zhao T, Li H, Liu X, Gong E, Xie S, Gao B, An L, Chen G, Ma X, Wang C.   +12 more
europepmc   +1 more source

Intima‐Media Thickness Progression Rate and Primary Unassisted Patency Failure in Arteriovenous Fistulas: A Prospective Cohort Study

Hemodialysis International, EarlyView.
ABSTRACT Background Failure of autogenous arteriovenous fistulas (AV fistulas) due to venous neointimal hyperplasia is a major clinical challenge. Whether the rate of progression in venous intima‐media thickness predicts primary unassisted patency failure remains unknown.
Gen Li, Zhengjiang Cao
wiley   +1 more source

Survival and Treatment Patterns in Stage III Inflammatory and Noninflammatory Breast Cancer.

JAMA Netw Open
Leone JP, Leone J, De Placido P, Nakhlis F, Schlam I, Hirko KA, Hazra A, Troll E, Bellon JR, Vallejo CT, Lin NU, Tolaney SM, Lynce F.   +12 more
europepmc   +1 more source

Enhancing ecological risk assessment of dioxins in aquatic environments: AHR diversity and species sensitivity differences in tiger puffer (Takifugu rubripes). [PDF]

J Hazard Mater
Xue Z, Zhang W, Ren A, Karchner SI, Franks DG, Zong Y, Ma Y, Wang J, Xu Y, Li J, Ding N, Liu C, Hahn ME, Zhao B.   +13 more
europepmc   +1 more source

Retention in care among women with HIV: A systematic review of treatment continuity during pregnancy and postpartum

HIV Medicine, EarlyView.
Abstract Introduction Pregnant women with HIV are at risk of reduced engagement in HIV care during pregnancy and postpartum. Retention in care, defined as continuous engagement in HIV‐related treatment and follow‐up, is essential to achieve virological suppression and prevent vertical transmission.
Stine Hansen, Klara Tetzschner Madsen, Nina Weis, Ellen Moseholm   +3 more
wiley   +1 more source

Cardiovascular morbidity following epilepsy: A nationwide retrospective cohort study in South Korea. [PDF]

Epilepsia Open
Bae Y, Kang C, Lee Y, Cho H, Jung H, Lee SW.   +5 more
europepmc   +1 more source

Influence of MASLD and MAFLD on long‐term extrahepatic cancer incidence and cancer mortality in regional Australia

Internal Medicine Journal, EarlyView.
Abstract Background and Aims Metabolic (dysfunction)‐associated steatotic liver disease (MASLD) has been linked to an increased risk of extrahepatic cancers. Whether MASLD or metabolic (dysfunction)‐associated fatty liver disease (MAFLD) is associated with an increased risk of extrahepatic cancer incidence or death in Australia is unknown. Methods This
Karl Vaz, William Kemp, Ammar Majeed, John Lubel, Dianna J Magliano, Kristen M Glenister, Lisa Bourke, David Simmons, Stuart K. Roberts   +8 more
wiley   +1 more source

Accelerated neurostimulation protocols for auditory hallucinations: a systematic review and meta-analysis. [PDF]

Front Psychiatry
Hotz T, Kosyakova N, Sharma M.
europepmc   +1 more source

Functional Endoscopic Sinus Surgery in Adults With CRSwNP Treated With Mepolizumab: Airway Physiology Outcomes From a Randomised Controlled Trial

Clinical &Experimental Allergy, EarlyView.
Jens Tidemandsen, Anne Sophie Homøe, Peter G. Gibson, Howraman Meteran, Kasper Aanæs, Morten Hostrup, Marie Høxbro, Vibeke Backer   +7 more
wiley   +1 more source