Results 291 to 300 of about 688,717 (308)

Synthetic Analogs Tailor Native AI-2 Signaling Across Bacterial Species

Journal of the American Chemical Society, 2010
The widespread use of antibiotics and the emergence of resistant strains call for new approaches to treat bacterial infection. Bacterial cell-cell communication or "quorum sensing" (QS) is mediated by "signatures" of small molecules that represent targets for "quenching" communication and avoiding virulent phenotypes.
Varnika, Roy, Jacqueline A I, Smith, Jingxin, Wang, Jessica E, Stewart, William E, Bentley, Herman O, Sintim   +5 more
openaire   +2 more sources

Inhibition of Pseudomonas aeruginosa quorum sensing by AI-2 analogs

Bioorganic & Medicinal Chemistry Letters, 2009
Autoinducer-2 (AI-2) has been suggested to serve as a universal interspecies quorum sensing signaling molecule. We have synthesized a set of AI-2 analogs with small incremental changes in alkyl substitution on C-2 and evaluated them for their agonistic and antagonistic potential as quorum sensing (QS) attenuators in two different bacterial species ...
Hadas, Ganin, Xu, Tang, Michael M, Meijler   +2 more
openaire   +2 more sources

AI^2: Training a Big Data Machine to Defend

2016 IEEE 2nd International Conference on Big Data Security on Cloud (BigDataSecurity), IEEE International Conference on High Performance and Smart Computing (HPSC), and IEEE International Conference on Intelligent Data and Security (IDS), 2016
We present AI2, an analyst-in-the-loop security system where Analyst Intuition (AI) is put together with state-of-the-art machine learning to build a complete end-to-end Artificially Intelligent solution (AI). The system presents four key features: a big data behavioral analytics platform, an outlier detection system, a mechanism to obtain feedback ...
Kalyan Veeramachaneni, Ignacio Arnaldo, Vamsi Korrapati, Constantinos Bassias, Ke Li   +4 more
openaire   +1 more source

amor ais 2

2023
Entre 2006 e 2011 Francisco Providência teve presença diária na secção de opinião do Jornal de Notícias, ilustrando os textos dos seus convidados. Essas ilustrações, realizadas no limite da escassez de meios a esferográfica sobre papel A4, eram produzidas sob a tensão da corrida contra o tempo, muitas vezes em breves minutos e posteriormente enviadas ...
openaire   +1 more source

Detection of Autoinducer (AI-2)-Like Activity in Food Samples

2010
The contamination, survival, and possible foodborne disease outbreaks are major issues confronting the food industry. However, from a microbial perspective, any food whether natural or processed is just another environmental niche that is available for colonization.
Kirthiram K, Sivakumar, Palmy R, Jesudhasan, Suresh D, Pillai   +2 more
openaire   +2 more sources

Cross Species Quorum Quenching Using a Native AI-2 Processing Enzyme

ACS Chemical Biology, 2010
Bacterial quorum sensing (QS) is a cell-cell communication process, mediated by signaling molecules, that alters various phenotypes including pathogenicity. Methods to interrupt these communication networks are being pursued as next generation antimicrobials.
Varnika, Roy, Rohan, Fernandes, Chen-Yu, Tsao, William E, Bentley   +3 more
openaire   +2 more sources

Developing next generation antimicrobials by intercepting AI-2 mediated quorum sensing

Enzyme and Microbial Technology, 2011
Bacteria have been evolving antibiotic resistance since their discovery in the early twentieth century. Most new antibiotics are derivatives of older generations and there are now bacteria that are virtually resistant to almost all antibiotics. This poses a global threat to human health and has been classified as a clinical "super-challenge", which has
Varnika, Roy, Bryn L, Adams, William E, Bentley   +2 more
openaire   +2 more sources

Boron Binding with the Quorum Sensing Signal AI-2 and Analogues

Organic Letters, 2004
[reaction: see text] The unstable bacterial metabolic product, DPD, and the related natural product, laurencione, are shown to have a high affinity for borate complexation, through the hydrated analogue. The boron complex of DPD is Vibrio harveyi AI-2, an interspecies quorum sensing signal in bacteria, and an affinity column with a borate resin is ...
Martin F, Semmelhack, Shawn R, Campagna, Charlotte, Hwa, Michael J, Federle, Bonnie L, Bassler   +4 more
openaire   +2 more sources

AI-2 to the rescue against antibiotic-induced intestinal dysbiosis?

Trends in Microbiology, 2015
The downside of antibiotic treatment of infectious diseases is a disturbed intestinal microbiota leading to reduced resistance against pathogen colonization. Work by Thompson et al. now suggests that antibiotic-induced intestinal dysbiosis can partially be counterbalanced by artificially increasing the levels of autoinducer-2 (AI-2), a well-known ...
Zhongke, Sun, Verena, Grimm, Christian U, Riedel   +2 more
openaire   +2 more sources

AI-2 analogs and antibiotics: a synergistic approach to reduce bacterial biofilms

Applied Microbiology and Biotechnology, 2012
Quorum sensing (QS), the process of autoinducer-mediated cell-cell signaling among bacteria, facilitates biofilm formation, virulence, and many other multicellular phenotypes. QS inhibitors are being investigated as antimicrobials because of their potential to reduce symptoms of infectious disease while slowing the emergence of resistant strains ...
Varnika, Roy, Mariana T, Meyer, Jacqueline A I, Smith, Sonja, Gamby, Herman O, Sintim, Reza, Ghodssi, William E, Bentley   +6 more
openaire   +2 more sources