Results 101 to 110 of about 2,041,778 (278)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Identification of Natural Inhibitors Targeting the NS3-Like Helicase Enzyme of Emerging Tick Alongshan Virus

Journal of Pure and Applied Microbiology
In this study, considering the vital biological importance of the Alongshan virus NS3-like helicase enzyme, several machine learning and artificial intelligence-based software and servers were used to identify compounds that exhibited the best binding ...
Roba M.S. Attar
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Tracing English interference in AI-generated German: An analysis of word order and syntactic fronting

Large language models (LLMs) constitute a transformative advancement in natural language processing, yet their development remains disproportionately skewed toward English.
Valentinelli, Paolo
core   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

AI in Energy [PDF]

The rapid integration of Artificial Intelligence (AI), 5G, and upcoming 6G technologies into the energy sector signifies a transformative and long-term transitional shift towards a more sustainable and efficient future enabled by myriads of digital ...
Vermesan, Ovidiu, Funk, Hannah, Al-Naday, Mays, Cerny, Ondrej, Atmojo, Udayanto Dwi, Svenn, Flemming, Krukowski, Artur, Gusmeroli, Sergio, Karagiannis, Vasileios, Hamzeh Aghdam, Farid, Filipovic, Damir, Hovsto, Asbjorn, Zavodovski, Aleksandr, Gebremehdin, Alemayehu, Matta, Andrea, Frigerio, Nicla, Silva, Fabio, Rasti, Mehdi, Samovich, Natalie, Mukherjee, Avishek, Soldatos, Ioannis, Frascolla, Valerio, Cornec, Léo, Pongracz, Eva, Kung, Antonio, Zachäus, Carolin, Etminan, Ghazal   +26 more
core  

AI Robotics

Artificial intelligence (AI) robots can learn from their experiences, make decisions in real time, understand natural language and human gestures, and utilize computer vision to perceive and comprehend their environments.
Khanna, Vinod Kumar
core   +1 more source

AI for Low-Code for AI

Proceedings of the 29th International Conference on Intelligent User Interfaces
Low-code programming allows citizen developers to create programs with minimal coding effort, typically via visual (e.g. drag-and-drop) interfaces. In parallel, recent AI-powered tools such as Copilot and ChatGPT generate programs from natural language instructions. We argue that these modalities are complementary: tools like ChatGPT greatly reduce the
Nikitha Rao, Jason Tsay, Kiran Kate, Vincent J. Hellendoorn, Martin Hirzel   +4 more
openaire   +2 more sources

Prompts for generative artificial intelligence in legal discourse

RUDN Journal of Law
The development of generative models of artificial intelligence (AI) poses new challenges for legal science and practice. This requires understanding of the legal nature of prompts (queries to AI) and development of appropriate legal regulation.
Alexander E. Kirpichev
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source