Results 121 to 130 of about 2,041,778 (278)

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Queer Reflections on AI

This volume offers a socio-technical exploration of Artificial Intelligence (AI) and the way it reflects and reproduces certain normative representations of gender and sexuality, to ultimately guide more diverse and radical discussions of life with ...

core   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

AI Accelerator Announces Award Winners

The Department of Air Force (DAF)-MIT AI Accelerator is a unique collaboration designed to advance the field of AI to improve DAF operations and address broader societal needs.
Accelerator, AI
core  

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

The Genesis of AI by AI Integrated Circuit: Where AI Creates AI

Electronics
The typical Integrated Circuit (IC) development process commences with formulating specifications in natural language and subsequently proceeds to Register Transfer Level (RTL) implementation. RTL code is traditionally generated through manual efforts, using Hardware Description Languages (HDL) such as VHDL or Verilog.
Emilio Isaac Baungarten-Leon, Susana Ortega-Cisneros, Mohamed Abdelmoneum, Ruth Yadira Vidana Morales, German Pinedo-Diaz   +4 more
openaire   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Intersymbolic AI

AbstractThis perspective piece calls for the study of the new field of Intersymbolic AI, by which we mean the combination of symbolic AI, whose building blocks have inherent significance/meaning, with subsymbolic AI, whose entirety creates significance/effect despite the fact that individual building blocks escape meaning.
openaire   +4 more sources

Responsible AI: the good, the bad, the AI

AI and Ethics
The rapid proliferation of artificial intelligence across organizational contexts has generated profound strategic opportunities while introducing significant ethical and operational risks. Despite growing scholarly attention to responsible AI, extant literature remains fragmented and is often adopting either an optimistic stance emphasizing value ...
Akbar Anbar Jafari, Cagri Ozcinar, Gholamreza Anbarjafari   +2 more
openaire   +3 more sources