Results 71 to 80 of about 180,460 (261)
Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
Harmonised standards to the AI Act – for medical devices, too
Finnish Journal of eHealth and eWelfareThe European Union artificial intelligence act (AI Act) establishes the rules for the application of artificial intelligence (AI) systems within the European Union.
Alpo Olavi Värri
doaj +1 more source
Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus
FEBS Open Bio, EarlyView.BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima +7 more
wiley +1 more source
Heterotropic regulation and negative homotropic cooperativity
FEBS Open Bio, EarlyView.We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source
AI Copilot: The concept of an AI agent playing different roles in various narratives is quite fascinating and is often explored in the realm of artificial intelligence through multi-agent systems and role-based AI models. In these systems, an AI can be designed to assume different roles or personas, adapting its behavior and responses according to the ...
openaire +1 more source
FEBS Open Bio, EarlyView.The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti +5 more
wiley +1 more source
The EU AI Act: Law of Unintended Consequences?
Technology and RegulationAfter long deliberations, the highly anticipated AI Act is almost there. Although it is yet to be seen what the effects of this landmark regulation are going to be, it is important to already prepare for what can be expected and to identify possible dynamics regarding competencies, implementation, and enforcement.
openaire +3 more sources
Shortcomings of the AI Act [PDF]
After the much-awaited vote of the 13th March 2024 by the European Parliament, it is time to begin evaluating the state of fundamental rights in light of the AI Act. In this blog post, three areas of potential inconsistencies and risks are examined: differentiation of provider and deployer, biometrics used in real-time and post-factum, and the ...
openaire +1 more source
Journal of Educational, Cultural and Psychological StudiesGENERATIVE ARTIFICIAL INTELLIGENCE: RISKS AND OPPORTUNITIES IN EDUCATION. THE «COUNSELORBOT» PROJECT FOR TUTORIAL SUPPORT Abstract Artificial intelligence (AI) is progressively entering educational practices, influencing teaching and learning ...
Daniele Dragoni, Massimo Margottini
doaj +1 more source
Cell surface CD11c as a neutrophil aging marker molecule
FEBS Open Bio, EarlyView.Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki +5 more
wiley +1 more source