Results 1 to 10 of about 3,157,763 (219)

Proteome-wide analysis of protein abundance and turnover remodelling during oncogenic transformation of human breast epithelial cells [version 1; referees: 2 approved, 1 approved with reservations]

Wellcome Open Research, 2018
Background: Viral oncogenes and mutated proto-oncogenes are potent drivers of cancer malignancy. Downstream of the oncogenic trigger are alterations in protein properties that give rise to cellular transformation and the acquisition of malignant cellular
Tony Ly, Aki Endo, Alejandro Brenes, Marek Gierlinski, Vackar Afzal, Andrea Pawellek, Angus I. Lamond   +6 more
doaj   +1 more source

Restoration of CpG Methylation in The Egf Promoter Region during Rat Liver Regeneration

Cell Journal, 2015
Epidermal growth factor (EGF) is an important factor for healing after tissue damage in diverse experimental models. It plays an important role in liver regeneration (LR).
Deming Li, Ziwei Li, Xueqiang Guo, Cunshuan Xu   +3 more
doaj  

Internal desynchrony of the hepatic circadian system with dissociated systemic rhythms in middle-aged mice under social jet lag-like conditions

Scientific Reports
Social jet lag (SJL) leads to a misalignment between the circadian clock and social time. In this study, we investigated the effects of weekly shifts in light-dark (LD) conditions: two days per week with 6-h delayed LD cycles (simulating Saturday and ...
Saki Fukushima, Dan Yang, Tatsumi Morita, Kenshiro Aragane, Sae Yamakawa, Kaito Kurogi, Ryohei Matsuo, Tiantian Ma, Keisuke Ikegami, Mitsuhiro Furuse, Shinobu Yasuo   +10 more
doaj   +1 more source

Characterization of Microbes Involved in Anaerobic Fermentation of Various Jiaosu

International Journal of Food Science
Jiaosu is a fermentation product using microorganisms to transform organic materials into bioactive ingredients, which plays an important role in food industry, healthcare, and environmental protection.
Ying Wang, Shuo Feng, Shi-min Liu, Zhi-sheng Zheng, Ling-xiao Wang, Xiu-fang Hu   +5 more
doaj   +1 more source

The multiple roles of Rab9 in the endolysosomal system

Communicative & Integrative Biology, 2016
The small GTPase Rab9 has long been described as a protein that mediates endosome-to-trans-Golgi Network (TGN) transport, and specifically mannose-6-phospate receptor (MPR) recycling.
Ana Kucera, Oddmund Bakke, Cinzia Progida   +2 more
doaj   +1 more source

Sex-dependent effects of chronic jet lag on circadian rhythm and metabolism in mice

Biology of Sex Differences
Background The circadian clock integrates external environmental changes into the internal physiology of organisms. Perturbed circadian clocks due to misaligned light cycles increase the risk of diseases, including metabolic disorders.
Tiantian Ma, Ryohei Matsuo, Kaito Kurogi, Shunsuke Miyamoto, Tatsumi Morita, Marina Shinozuka, Fuka Taniguchi, Keisuke Ikegami, Shinobu Yasuo   +8 more
doaj   +1 more source

The interplay between lipid metabolism, cancer progression and anti-cancer immunity

Experimental and Molecular Medicine
The tumour microenvironment (TME) consists of a complex ecosystem of tumour cells, stromal elements, extracellular matrix, fibroblasts and diverse immune-cell populations. Although traditional cancer therapies have primarily focused on eliminating tumour
Choong-Hyun Koh, Yoosun Lee, Il-Kyu Kim, Yeonseok Chung   +3 more
doaj   +1 more source

Biosynthetic gene clusters from uncultivated soil bacteria of the Atacama Desert

mSphere
Soil microorganisms mediate several biological processes through the secretion of natural products synthesized in specialized metabolic pathways, yet functional characterization in ecological contexts remains challenging.
Constanza M. Andreani-Gerard, Verónica Cambiazo, Mauricio González   +2 more
doaj   +1 more source

Exploring the cancerous nexus: the pivotal and diverse roles of USP39 in cancer development

Discover Oncology
The ubiquitin–proteasome system enables post-transcriptional protein modification and is a major pathway for the degradation of most of them in eukaryotic cells.
Yujing Chen, Jingyi Zhang, Jinfeng Yang, Jiawei Zhao, Xiaotong Guo, Juzheng Zhang, Jinfeng Gan, Weijia Zhao, Siqi Chen, Xinwen Zhang, Yi Lin, Jiamin Jin   +11 more
doaj   +1 more source

Exogenous melatonin mitigates cadmium stress on cotton seed germination: physiological, biochemical, and transcriptomic insights

BMC Plant Biology
Background Cadmium (Cd) is a prevalent and toxic heavy metal widely present in soils. Cotton (Gossypium hirsutum L.), which readily accumulates Cd, exhibits inhibited seed germination under Cd stress. Melatonin (MT), a potent indoleamine antioxidant, has
Jian Wang, Bin Lu, Xinying Ma, Shasha Liu, Jialin Li, Ke Zhang, Hongchun Sun, Lingxiao Zhu, Yongjiang Zhang, Liantao Liu, Zhiying Bai, Cundong Li   +11 more
doaj   +1 more source