Results 21 to 30 of about 2,985,031 (266)

Upfront admixing antibodies and EGFR inhibitors preempts sequential treatments in lung cancer models

EMBO Molecular Medicine, 2021
Some antibacterial therapies entail sequential treatments with different antibiotics, but whether this approach is optimal for anti‐cancer tyrosine kinase inhibitors (TKIs) remains open. EGFR mutations identify lung cancer patients who can derive benefit
Ilaria Marrocco, Donatella Romaniello, Itay Vaknin, Diana Drago‐Garcia, Roni Oren, Mary Luz Uribe, Nishanth Belugali Nataraj, Soma Ghosh, Raya Eilam, Tomer‐Meir Salame, Moshit Lindzen, Yosef Yarden   +11 more
doaj   +1 more source

ExOrthist: a tool to infer exon orthologies at any evolutionary distance

Genome Biology, 2021
Several bioinformatic tools have been developed for genome-wide identification of orthologous and paralogous genes. However, no corresponding tool allows the detection of exon homology relationships.
Yamile Márquez, Federica Mantica, Luca Cozzuto, Demian Burguera, Antonio Hermoso-Pulido, Julia Ponomarenko, Scott W. Roy, Manuel Irimia   +7 more
doaj   +1 more source

A subset of conserved mammalian long non-coding RNAs are fossils of ancestral protein-coding genes

Genome Biology, 2017
Background Only a small portion of human long non-coding RNAs (lncRNAs) appear to be conserved outside of mammals, but the events underlying the birth of new lncRNAs in mammals remain largely unknown.
Hadas Hezroni, Rotem Ben-Tov Perry, Zohar Meir, Gali Housman, Yoav Lubelsky, Igor Ulitsky   +5 more
doaj   +1 more source

The association between e-cigarette use and asthma among never combustible cigarette smokers: behavioral risk factor surveillance system (BRFSS) 2016 & 2017

BMC Pulmonary Medicine, 2019
Background E-cigarette use prevalence has grown rapidly in the US. Despite the popularity of these products, few acute exposure toxicity studies exist, and studies on long-term pulmonary health effects are limited.
Albert D. Osei, Mohammadhassan Mirbolouk, Olusola A. Orimoloye, Omar Dzaye, S. M. Iftekhar Uddin, Zeina A. Dardari, Andrew P. DeFilippis, Aruni Bhatnagar, Michael J. Blaha   +8 more
doaj   +1 more source

Phenotyping Diabetes Mellitus on Aggregated Electronic Health Records from Disparate Health Systems

Pharmacoepidemiology, 2023
Background: Identifying patients with diabetes mellitus (DM) is often performed in epidemiological studies using electronic health records (EHR), but currently available algorithms have features that limit their generalizability.
Hui Xing Tan, Rachel Li Ting Lim, Pei San Ang, Belinda Pei Qin Foo, Yen Ling Koon, Jing Wei Neo, Amelia Jing Jing Ng, Siew Har Tan, Desmond Chun Hwee Teo, Mun Yee Tham, Aaron Jun Yi Yap, Nicholas Kai Ming Ng, Celine Wei Ping Loke, Li Fung Peck, Huilin Huang, Sreemanee Raaj Dorajoo   +15 more
doaj   +1 more source

Irrigation has a higher impact on soil bacterial abundance, diversity and composition than nitrogen fertilization

Scientific Reports, 2021
The aim of this study was to assess the effects of irrigation frequency and nitrogen fertilization rate on the abundance, diversity, and composition of soil bacteria in winter wheat.
Haoran Li, Hongguang Wang, Bin Jia, Dongxiao Li, Qin Fang, Ruiqi Li   +5 more
doaj   +1 more source

CTCF and cohesin promote focal detachment of DNA from the nuclear lamina

Genome Biology, 2022
Background Lamina-associated domains (LADs) are large genomic regions that are positioned at the nuclear lamina. It has remained largely unclear what drives the positioning and demarcation of LADs.
Tom van Schaik, Ning Qing Liu, Stefano G. Manzo, Daan Peric-Hupkes, Elzo de Wit, Bas van Steensel   +5 more
doaj   +1 more source

SUMO: regulating the regulator.

Cell division, 2006
Post-translational modifiers of the SUMO (Small Ubiquitin-related Modifier) family have emerged as key regulators of protein function and fate. While the past few years have seen an enormous increase in knowledge on SUMO enzymes, substrates, and consequences of modification, regulation of SUMO conjugation is far from being understood. This brief review
Bossis, G., Melchior, F.
openaire   +4 more sources

Cup‐Like Nuclei Is a Hallmark of DUX4/ERG Acute Lymphoblastic Leukemia and Reveals Cytoplasmic Mitochondria Accumulation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Cup‐like nuclei are a distinctive morphological feature observed in certain cases of acute lymphoblastic leukemia (ALL). We provide evidence that they characterize DUX4/ERG ALL independently of IKZF1 deletion and reveal marked mitochondrial accumulation in this ALL subset.
Chloé Arfeuille, Hugo Roux, Odile Fenneteau, Aurélie Caye‐Eude, Alexia Kinoo, Yoann Vial, André Baruchel, Marion Strullu, Elodie Lainey, Hélène Cavé   +9 more
wiley   +1 more source

The Combined Effect of Obesity and Contraceptive Use on Pulmonary Embolism in Adolescent Females Residing in the United States

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Combined oral contraceptive (COC) use in obese adult women dramatically increases the relative risk of developing a pulmonary embolism (PE). The risk of a PE in obese adolescent females taking contraceptives is currently unknown. The purpose of this investigation was to determine the effect of body mass index (BMI) and contraceptive
John Puetz, Joanne Salas
wiley   +1 more source