Results 51 to 60 of about 26,062 (253)
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
BioData Mining, 2023 Background The governance of health systems is complex in nature due to several intertwined and multi-dimensional factors contributing to it. Recent challenges of health systems reflect the need for innovative approaches that can minimize adverse ...
Maryam Ramezani +5 more
doaj +1 more source
A Multilevel Framework for AI Governance
This paper has been accepted for publication and is forthcoming in The Global and Digital Governance Handbook. Cite as: Choung, H., David, P., & Seberger, J.S. (2023). A multilevel framework for AI governance. The Global and Digital Governance Handbook.
Hyesun Choung +2 more
openaire +2 more sources
Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
FEBS Open Bio, EarlyView.Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
Framing governance for a contested emerging technology:insights from AI policy
Policy & Society, 2021 This paper examines how the governance in AI policy documents have been framed as way to resolve public controversies surrounding AI. It draws on the studies of governance of emerging technologies, the concept of policy framing, and analysis of 49 recent
Inga Ulnicane +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
AI in the Government: Responses to Failures
, 2022 Artificial Intelligence (AI) is pervading the government and transforming how public services are provided to consumers—from allocation of government benefits to enforcement of the law, monitoring of risks, and provision of services. Despite technological improvements, AI systems are fallible and may err.
Chiara Longoni, Luca Cian, Ellie Kyung
openaire +1 more source