Results 61 to 70 of about 1,762,290 (292)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Russia’s securitised approach to AI sovereignty

The African Journal of Information and Communication
In the context of the world’s major powers competing for dominance in the artificial intelligence (AI) realm, Russia aims to become a global leader in AI development.
Alexander Ignatov, Danil Kerimi
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Construction and implementation strategy of data governance system in AI scenarios

管道保护
As AI technology becomes increasingly integrated into oil and gas storage and transportation, data governance in AI scenarios faces significant structural contradictions and challenges.
Liang LI, Hui JIANG, Yichun SONG, Buwei LI   +3 more
doaj   +1 more source

A Multilevel Framework for AI Governance

This paper has been accepted for publication and is forthcoming in The Global and Digital Governance Handbook. Cite as: Choung, H., David, P., & Seberger, J.S. (2023). A multilevel framework for AI governance. The Global and Digital Governance Handbook.
Hyesun Choung, Prabu David, John S. Seberger   +2 more
openaire   +2 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Cross-cultural insights from the AGILE index 2025 on aligning AI governance with the SDGs

Societal Impacts
The uneven alignment between AI governance and the Sustainable Development Goals (SDGs) threatens to widen global inequities and slow progress toward shared sustainability targets.
Ammar Younas, Cunqing Huangfu, Yi Zeng
doaj   +1 more source

Robust Vehicle Number Plate Text Recognition and Data Analysis Using Tesseract Ocr [PDF]

ITM Web of Conferences
To detect the vehicle number plate the system should understand the character and integers determined on vehicles. The proposed methodology holds three phases: pre-process, extraction of features and recognition of text.
Padmaja G., Pesaru Swetha, Reddy Desidi Narsimha, Kumari D. Anitha, Maram Shiva Prasad   +4 more
doaj   +1 more source