Results 81 to 90 of about 1,762,290 (292)

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

The establishment of an international AI agency: an applied solution to global AI governance

International Affairs
Achieving sustainable, inclusive, fair and binding international regulation in the field of artificial intelligence (AI) is one of the most critical questions of our time.
M. Robinson
semanticscholar   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

In Oxford Handbook on AI Governance: The Role of Workers in AI Ethics and Governance.

CoRR, 2021
While the role of states, corporations, and international organizations in AI governance has been extensively theorized, the role of workers has received comparatively little attention. This chapter looks at the role that workers play in identifying and mitigating harms from AI technologies. Harms are the causally assessed impacts of technologies. They
Nedzhvetskaya, Nataliya, Tan, JS
openaire   +2 more sources

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

AI Governance in a Complex and Rapidly Changing Regulatory Landscape: A Global Perspective

Humanities and Social Sciences Communications
The rapid advancement and deployment of Artificial Intelligence (AI) poses significant regulatory challenges for societies. While it has the potential to bring many benefits, the risks of commercial exploitation or unknown technological dangers have led ...
Esmat Zaidan, I. Ibrahim
semanticscholar   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Revolutionizing AI Governance: Addressing Bias and Ensuring Accountability Through the Holistic AI Governance Framework

International Journal of Advanced Computer Science and Applications
—Artificial intelligence (AI) possesses the capacity to transform numerous facets of our existence; however, it concomitantly engenders considerable risks associated with bias and discrimination.
I. Atoum
semanticscholar   +1 more source

Where Are the AI Governance Roles? An Early-Stage Empirical Mapping of Presence, Absence, and Structure in Organisational AI Oversight

Businesses
Purpose: This research investigates where formal responsibility for artificial intelligence (AI) lies within organisations and how the presence, absence, or structure of that responsibility affects their ability to govern AI effectively.
Victor Frimpong, Ortopah Kojo Botchey
doaj   +1 more source