Results 191 to 200 of about 2,744,223 (310)

You aren't going to like what comes after America: Europe and global health after 2025. [PDF]

Eur J Public Health
Greer SL.
europepmc   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Long-term complete radiological response to immunotherapy in a patient with metastatic NSCLC and active rheumatoid arthritis. [PDF]

Oxf Med Case Reports
Roy E, Jomeh AAE, Xenophontos E, Charalambous H.   +3 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Association between comorbidity burden and glycaemic profiles in adults with type 1 diabetes using hybrid closed-loop systems. [PDF]

Intern Med J
Syed A, Konantambigi A, Shenoy V, Puri G, Deshmukh H.   +4 more
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Effect of social support and social network on the risk of hearing aids abandonment among older adults with hearing loss. [PDF]

BMC Geriatr
Fuentes-López E, Terán-Tapia D, Nieman CL, Hormazábal X, Marcotti A.   +4 more
europepmc   +1 more source

Buffer gradient gels and 35S label as an aid to rapid DNA sequence determination.

Proceedings of the National Academy of Sciences of the United States of America, 1983
M. Biggin, T. Gibson, G. Hong
semanticscholar   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Ethical Challenges Encountered by Humanitarian Aid Workers in Temporary Displacement Camps in the Context of Covid-19. [PDF]

Public Health Ethics
Mellett R, Hunt M.
europepmc   +1 more source