Status and future of recombinant adeno‐associated virus vector manufacturing
Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley +1 more source
Duration and association with protection of NANP-repeat-specific and C-terminus-specific anti-circumsporozoite protein IgG responses following RTS,S/AS01<sub>E</sub> vaccination: an observational ancillary immunological study of a phase 3 clinical trial. [PDF]
Lara-Escandell M +26 more
europepmc +1 more source
ABSTRACT Background and Objectives This study applied linear programming to optimize taioba (Xanthosoma sagittifolium) leaf flour (TLF) incorporation in wheat bread, balancing nutritional enrichment and technological quality. Findings Breads containing 0%–15% TLF (flour basis) were produced and evaluated for composition, dough expansion, specific ...
Diana Jessica Souza Guimarães +3 more
wiley +1 more source
MXenes as a Versatile Platform for High‐Energy‐Density Asymmetric Supercapacitors
MXenes with high conductivity and tunable surface chemistry are reviewed as advanced electrodes for asymmetric supercapacitors. MAX‐phase synthesis, surface and interlayer engineering, defect modulation, and composite designs are discussed, highlighting enhanced ion transport, pseudocapacitance, energy density, cycling stability, and sustainable routes
Seul‐Yi Lee +3 more
wiley +1 more source
Beyond Furnaces: Harnessing In Situ Joule Heating for Efficient C1 Catalysis
Joule‐heated catalysis directly converts electrical energy into localized heat within conductive catalysts, overcoming the heat‐transfer limitations of conventional furnaces. This review summarizes recent advances in C1 molecule conversion, including CO2 methanation, reforming for hydrogen production, and HCHO/CO oxidation, while highlighting ...
Xue Kong +8 more
wiley +1 more source
Operational performance of a programmatic mass drug administration campaign for malaria in southern Mozambique: a comprehensive mixed-methods evaluation of implementation outcomes. [PDF]
Fuente-Soro L +11 more
europepmc +1 more source
Titanium‐Catalyzed Diastereoselective Keto‐ and Iminonitrile Cyclizations
The titanium(III)‐catalyzed diastereoselective cyclization of readily‐available substituted ketonitriles gives cyclopentanones in good yield and stereoselectivity. Subsequent 1,2‐addition allows the preparation of cyclopentyls with three consecutive stereocenters.
Christoph Kern +4 more
wiley +1 more source
Use of knowledge translation products from health technology assessment: a prospective observational study. [PDF]
Baradaran A +7 more
europepmc +1 more source
Cyclopropylamines have emerged as powerful photocatalytic building blocks. Upon light‐induced single‐electron oxidation, they undergo strain‐release ring opening to generate distonic iminium radicals that enable diverse transformations, including ring‐opening functionalization, formal [3 + 2] cycloadditions, radical cascades, and asymmetric bond ...
Maria Chiara Cabua +3 more
wiley +1 more source
Examining Quality of Work Life in Atlantic Canadian Long-Term Care Homes: Protocol for a Cross-Sectional Survey Study. [PDF]
Keefe JM +6 more
europepmc +1 more source

