Results 201 to 210 of about 1,065,261 (297)

Opportunistic Coccidiosis in Brazil: Diagnostic Challenges and Epidemiological Gaps in Immunosuppressed Groups. [PDF]

J Trop Med
Zorrer WCF, Rinaldi E, de Freitas BR, de Albuquerque PMM, Rahal NM, Cunha RC, Bruhn FRP.   +6 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Over-the-counter hearing aids and integrated health-monitoring sensors: a review of clinical evidence and implementation. [PDF]

Front Digit Health
Itatani N, Zavaglia M.
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

[Professional practices and commitments in the care of people living with HIV/AIDS]. [PDF]

Cad Saude Publica
Metelski FK, Meirelles BHS, Silva MMD, Erdmann AL, Vendruscolo C, Abreu WJCP.   +5 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Clinical Characteristics of Patients With AIDS and <i>Talaromyces marneffei</i> Infection of the Central Nervous System: A Retrospective Observation Study. [PDF]

AIDS Res Treat
Li Y, He J, He X, Peng Y, Luo X, Xie X, Fu Y, Long H.   +7 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Development and Validation of a Patient-Centered Scale to Evaluate Decision Aid Usability and Information Overload. [PDF]

Med Decis Making
Pickersgill NA, Tin AL, Nalavenkata S, Austria MD, Stevanovic K, Bergengren O, Gonsky JP, Hamilton JG, Hay JL, Vickers AJ, Fagerlin A, Carlsson SV.   +11 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source