Results 231 to 240 of about 1,065,261 (297)

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

open access: yesMolecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler   +3 more
wiley   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

Scaling pleasure-based sexual and reproductive health: an impact and economic modelling study in 99 low- and middle-income countries. [PDF]

open access: yesBMJ Glob Health
Wong B   +13 more
europepmc   +1 more source

sVCAM-1 and Hematological Profiles Are Associated With CD4-Defined Disease Status in HIV Infection. [PDF]

open access: yesJ Med Virol
Almeida-Silva B   +8 more
europepmc   +1 more source

Transforming Tobacco Cessation Counselling in Primary Care: A Mixed-Methods Evaluation of the Shared Decision-Making Model. [PDF]

open access: yesTob Use Insights
Habfast-Robertson I   +7 more
europepmc   +1 more source

A Video-Based Support Tool to Enhance Code Status Discussions in Older Adults After Trauma: A Prospective Pilot Survey Study. [PDF]

open access: yesJ Am Geriatr Soc
Karpe AS   +10 more
europepmc   +1 more source

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