Results 81 to 90 of about 2,400,430 (354)

A working model for cytoplasmic assembly of H/ACA snoRNPs

FEBS Letters, EarlyView.
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Global Perspective of Novel Therapeutic Strategies for the Management of NeuroAIDS

Biomolecular Concepts, 2018
Among Human immunodeficiency virus (HIV) infected individuals, around two-thirds of patients present with neuroAIDS, where HIV-associated neurocognitive disorders (HAND), and HIV-associated dementia (HAD) are the most prevailing neurological ...
Kumar Swatantra, Maurya Vimal K, Dandu Himanshu R, Bhatt Madan LB, Saxena Shailendra K   +4 more
doaj   +1 more source

Novel and unscrutinized immune entities of the zebrafish gut

FEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil, Marine Mantel, Julia Soh, Serge Mostowy, Sylvia Brugman, Gilles Claude Vanwalleghem   +5 more
wiley   +1 more source

Iranian school students’ awareness of and attitude towards HIV/AIDS: a systematic review

International Journal of Adolescence and Youth, 2020
This paper attempts to assess the knowledge and attitude on HIV/AIDS among school students of Iran. The following data sources were searched for eligible studies: Medline, Science Direct, CINAHL, Scopus, Web of Science, SID, ISC, Magiran, and Google ...
Sakineh Dadipoor, Saeideh Shahsavari, Mohtasham Ghaffari, Sakineh Rakhshanderou, Ali Safari-Moradabadi   +4 more
doaj   +1 more source

Resources and Tools:A Step-by-Step Methodological Guide for Costing HIV/AIDS Activities [PDF]

, 2001
Many developing countries have recognized the need for comprehensive national reforms and comprehensive prevention, treatment, and care and support initiatives to reduce future transmission of and to meet the growing demand for HIV/AIDS services.
Huff-Rousselle, Maggie, Phillips , Margaret   +1 more
core  

The Impact of the Criminalization of HIV Non-Disclosure on the Health and Human Rights of “Black” Communities [PDF]

, 2013
The criminalization of HIV non-disclosure has become a hot topic for discussion and debate amongst human rights advocates, HIV/AIDS service providers, and people infected and affected by HIV/AIDS.
Wilson, Ciann L.
core   +3 more sources

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Assessing the Readiness of Nairobi Deaf Youth to Accept a Best-practice HIV/AIDS Intervention [PDF]

, 2014
After nearly forty years of HIV/AIDS research in the global community, data on HIV/AIDS in the Deaf population is still disproportionately neglected. No surveillance system is in place to monitor prevalence, awareness or mode of HIV infection in the Deaf
Morrell, Ke\u27ala
core   +1 more source

Clientelism and aid

Journal of Development Economics, 2008
Abstract Using a model of probabilistic voting, we analyze the impact of aid on the political equilibrium in the recipient country or region. We consider politicians with mixed motives: they are interested in promoting social welfare but also value the benefit of holding office.
Casamatta, Georges, Vellutini, Charles
openaire   +5 more sources