Results 31 to 40 of about 5,887,441 (327)

Digital Decision Aids to Support Decision-Making in Palliative and End-of-Life Dementia Care: Systematic Review and Meta-Analysis

Journal of Medical Internet Research
BackgroundMaking a care-related decision is a complex cognitive process. Patient decision aids could provide information on potential options about risks and benefits, incorporate individual values and preferences, and help people
Jie Zhong, Wei Liang, Tongyao Wang, Pui Hing Chau, Nathan Davies, Junqiang Zhao, Ho Nee Connie Chu, Chia Chin Lin   +7 more
doaj   +1 more source

Is the telomere length associated with neurocognitive disabilities in HIV-1-infected subjects?

Revista do Instituto de Medicina Tropical de São Paulo, 2018
Objective: We evaluated the association between cognitive deficits and leukocyte telomere length (LTL) in HIV-1-infected individuals. Design: 73 HIV-1-infected patients undergoing neuropsychological evaluation and 91 healthy controls were included in ...
Marilia Ladeira de Araújo, Wellington Duarte, Augusto César Penalva de Oliveira, Maria Rita Polo Gascón, Luiz Augusto Marcondes Fonseca, Raquel de Melo Alves Paiva, Bárbara Santana, Rodrigo Tocantins Calado, Jorge Casseb   +8 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

TNF-α contributes to caspase-3 independent apoptosis in neuroblastoma cells: role of NFAT. [PDF]

PLoS ONE, 2011
There is increasing evidence that soluble factors in inflammatory central nervous system diseases not only regulate the inflammatory process but also directly influence electrophysiological membrane properties of neurons and astrocytes.
Susana Alvarez, Almudena Blanco, Manuel Fresno, Ma Ángeles Muñoz-Fernández   +3 more
doaj   +1 more source

‘We do things together’. A case study of ‘couplehood’ in dementia [PDF]

, 2005
The value of the single case study is well established in dementia care with the seminal contributions of Alzheimer and Kitwood being based on the study of individuals.
Hellström, Ingrid, Lundh, Ulla, Nolan, Mike, Hellström, Ingrid,, Lundh, Ulla,, Nolan, Mike,   +5 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

The role of inflammation, oxidative stress and the apolipoprotein E genotype in HIV-associated cognitive impairment: a clinical, biochemical and neuro-imaging study [PDF]

, 2010
Includes abstract.Includes bibliographical references (leaves 113-135).Twenty percent of HIV-infected patients develop HIV-associated neurocognitive disorders (HAND), a spectrum of neurological diseases which includes HIV-associated dementia (HAD), a ...
Mahne, Anna Cecilia
core   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source

The Role of Reading Classic Fiction in Book Groups for People with Dementia is Better Understood through Use of a Qualitative Feasibility Study

Evidence Based Library and Information Practice, 2018
A Review of: Rimkeit, B.S. and Claridge, G. (2017). Peer reviewed: literary Alzheimer’s, a qualitative feasibility study of dementia-friendly book groups. New Zealand Library & Information Management Journal, 56(2), 14-22.
Joanne Marie Muellenbach
doaj   +1 more source