Results 131 to 140 of about 7,461,211 (270)

The Aims of Medicine [PDF]

BMJ, 1871
openaire   +2 more sources

Integrating multi-omics analysis and machine learning to refine molecular subtypes and prognostic assessment of lower-grade glioma. [PDF]

Mol Ther Oncol
Jiang Q, Yang AY, Mo GL, Mo LG, Deng T, Huang SN, Hou ST, Huang QR.   +7 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

A utopian aim [PDF]

British Dental Journal, 2017
openaire   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Editorial: Investigating lung biology, metabolism, and host susceptibility in mycobacterial infections. [PDF]

Front Cell Infect Microbiol
Chandra P, Roth AT, Ronacher K.
europepmc   +1 more source

Dynamic modeling of electroporation

, 2016
Electroporation of tissues is modeled by taking into account two kinds of currents flowing respectively inside the cell and in the extracellular medium. This model takes into account capacitive effects.
Poignard, Clair, Voyer, Damien, Silve, A., Mir, L., Scorretti, Riccardo   +4 more
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Surgical aim [PDF]

Journal of Hand Surgery (European Volume), 2016
openaire   +2 more sources

A Multicenter Retrospective Outcomes Analysis of Patients with Localized Synovial Sarcoma. [PDF]

Cancer Res Commun
Testa S, Zhou MY, Schulte BC, Wang VE, Kenny K, Peng A, Lohman M, Desai AM, Bockorny B, Baghian A, Schmidt DR, Bui NQ, Pan M, Ganjoo KN, Monga V.   +14 more
europepmc   +1 more source