Results 131 to 140 of about 13,348,905 (284)
Persisting Patronage: Challenges to Breaking Gender Barriers in Thai Elections
Journal of Current Southeast Asian AffairsThe 2023 elections witnessed the highest number of women in national parliament in Thailand's history. What explains this sharp rise in women's political leadership in Thailand?
Aim Sinpeng
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Piękny tulipan, trup i bez czystego cięcia. Bez-duszna estetyka Derridy
Teksty Drugie, 2016 This article explores a passage from Jacques Derrida’s book Truth in Painting, a discussion of the concept of beauty in Kant’s aesthetics. Dybel points out the original way in which Derrida reformulates this concept, attributing new meaning to its key ...
Paweł Dybel
doaj
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Bayesian efficiency analysis with a flexible form: The aim cost function [PDF]
Sampling;Bayesian ...
Koop, G., Osiewalski, J., Steel, M.F.J.
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Pilot estimates of glidepath and aim point during simulated landing approaches [PDF]
Pilot perceptions of glidepath angle and aim point were measured during simulated landings. A fixed-base cockpit simulator was used with video recordings of simulated landing approaches shown on a video projector.
Acree, C. W., Jr.
core +1 more source