Results 81 to 90 of about 3,902,056 (289)

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

A didactical note on the advantage of using two parameters in Hopf bifurcation studies

open access: yes, 2012
In order to maximize the information that a linearized stability analysis provides, one should work with two free parameters rather than one. Moreover, it is recommended to first consider coefficients in the characteristic equation as parameters and in a
Korvasová, K.   +7 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Structural Analysis of PfSec62-Autophagy Interacting Motifs (AIM) and PfAtg8 Interactions for Its Implications in RecovER-phagy in Plasmodium falciparum

open access: yesFrontiers in Bioengineering and Biotechnology, 2019
Autophagy is a degradative pathway associated with many pathological and physiological processes crucial for cell survival. During ER stress, while selective autophagy occurs via ER-phagy, the re-establishment of physiologic ER homeostasis upon ...
Ashalatha Sreshty Mamidi   +3 more
doaj   +1 more source

Co-dimension 2 Geodesic Active Contours for MRA Segmentation [PDF]

open access: yes, 1999
Automatic and semi-automatic magnetic resonance angiography (MRA)s segmentation techniques can potentially save radiologists larges amounts of time required for manual segmentation and cans facilitate further data analysis. The proposed MRAs segmentation
Faugeras, Olivier   +11 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

The Analysis of Visual Motion: From Computational Theory to Neuronal Mechanisms [PDF]

open access: yes, 1986
This paper reviews a number of aspects of visual motion analysis in biological systems from a computational perspective. We illustrate the kinds of insights that have been gained through computational studies and how these observations can be ...
Hildreth, Ellen C., Koch, Christof
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Evaluation of mobile health applications using the RE-AIM model: systematic review and meta-analysis

open access: yesFrontiers in Public Health
BackgroundThe Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) model has been used as an instrument to determine the impact of the intervention on health in digital format.
Emanuele Louise Gomes de Magalhães Jorge   +6 more
doaj   +1 more source

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