Results 51 to 60 of about 325,139 (297)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Characterization of Francisella species isolated from the cooling water of an air conditioning system. [PDF]

open access: yes, 2015
Strains of Francisella spp. were isolated from cooling water from an air conditioning system in Guangzhou, China. These strains are Gram negative, coccobacilli, non-motile, oxidase negative, catalase negative, esterase and lipid esterase positive.
Atwill, Edward   +6 more
core   +3 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Air Conditioning

open access: yesINTERANTIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT
The working principles and the basic features of air conditioning systems are introduced in this paper. With the improvement of standard of living, air-conditioning has widely been applied. The increasing demand for comfort air-conditioning has brought within the need for greater numbers of practical, technical and sales personal who have should ...
  +4 more sources

Effect of Compressor-Discharge-Cooler Heat-Exchanger Length Using Condensate Water on the Performance of a Split-Type Air Conditioner Using R32 as Working Fluid

open access: yesEnergies, 2022
The utilization of condensate water as a compressor-discharge cooler results in subcooling on the condenser outlet. On the other hand, a split-type air conditioner (A/C) with R32 as working fluid can provide higher compressor-discharge temperatures than ...
Kasni Sumeru   +5 more
doaj   +1 more source

Assessment of Factors Contributing to Refrigerator Cycling Losses [PDF]

open access: yes, 1993
Thermal mass effects, refrigerant dynamics, and interchanger transients are three factors affecting the transient and cycling performance of all refrigeration and air conditioning equipment.
Bullard, C.W., Rubas, P.J.
core  

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

open access: yesFEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold   +11 more
wiley   +1 more source

Applicability of energy consumption prediction models in a department store: A case study

open access: yesCase Studies in Thermal Engineering, 2023
Obtaining an accurate picture of energy consumption in public spaces is a critical first step for predicting and enhancing energy efficiency. In practice, such calculations are often complicated, necessitating use of artificial intelligence models which ...
Li-Yuan Chen   +3 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

open access: yesFEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi   +7 more
wiley   +1 more source

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