Results 41 to 50 of about 123,269 (263)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Indoor Air Quality Assessment Based on Human Physiology - Part 1. New Criteria Proposal

Acta Polytechnica, 2003
Human physiology research makes evident that the Weber-Fechner law applies not only to noise perception but also to the perception of other environmental components.
M. V. Jokl
doaj  

Analysis of national air pollutant emissions in 2020 and re-estimation results for emissions from past years (2016–2019)

Asian Journal of Atmospheric Environment
The National Air Emission Inventory and Research Center (NAIR) has refined emissions estimation methods to enhance the accuracy and reliability of national statistics on air pollutant emissions. The center estimated 2020 national emissions by applying 23
Seongwoo Choi, Dongjae Lee, Yera Choi, Kwonhee Choi, Eunji Shin, Hyungcheon Kim, Myeonggeun Cha, Hyeongdo Song, Chul Yoo   +8 more
doaj   +1 more source

Procesy zarządzania ryzykiem ekologicznym

Studia Ecologiae et Bioethicae, 2009
Risk management relies on identification, estimation, control and finance of potential risks. Excient process of management against alternate of ecological threat it’s people and nature resources protection before threats related to pollution of water ...
Marta Dołęga, Krzysztof Biernat
doaj   +1 more source

Association between ambient air pollutants and upper respiratory tract infection and pneumonia disease burden in Thailand from 2000 to 2022: a high frequency ecological analysis

BMC Infectious Diseases, 2023
Background A pertinent risk factor of upper respiratory tract infections (URTIs) and pneumonia is the exposure to major ambient air pollutants, with short term exposures to different air pollutants being shown to exacerbate several respiratory conditions.
Esther Li Wen Choo, A. Janhavi, Joel Ruihan Koo, Steve H. L. Yim, Borame L Dickens, Jue Tao Lim   +5 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Indoor Air Quality Assessment Based on Human Physiology - Part 2. Limits

Acta Polytechnica, 2003
In order to evaluate indoor air quality in practice it is necessary to establish limits, or more exactly, tolerable ranges for unadapted and adapted persons. The optimal value overwhelmingly corresponds to PD 20 %.
M. V. Jokl
doaj  

Air-mattress system for ballistocardiogram-based heart rate and breathing rate estimation

Heliyon, 2023
Sleep-related problems are widespread. Numerous devices for sleep monitoring are increasingly available, including smartwatches, sleep monitoring rings, etc. These devices accumulate and analyze a substantial quantity of physiological data. In this study,
Chun-Liang Lin, Zhen-Tai Sun, Yang-Yi Chen   +2 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source