Results 51 to 60 of about 3,035,907 (349)

Effect of Compressor-Discharge-Cooler Heat-Exchanger Length Using Condensate Water on the Performance of a Split-Type Air Conditioner Using R32 as Working Fluid

open access: yesEnergies, 2022
The utilization of condensate water as a compressor-discharge cooler results in subcooling on the condenser outlet. On the other hand, a split-type air conditioner (A/C) with R32 as working fluid can provide higher compressor-discharge temperatures than ...
Kasni Sumeru   +5 more
doaj   +1 more source

Humidity Effects in Mobile Air-Conditioning Systems [PDF]

open access: yes, 1997
A humidity addition system was installed in the mobile air-conditioning test facility. The system is able to produce relative humidities at the evaporator inlet in excess of 95% RH. The system is able to control the humidity to with ± 2% RH of a setpoint.
Whitchurch, M.R.
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Applicability of energy consumption prediction models in a department store: A case study

open access: yesCase Studies in Thermal Engineering, 2023
Obtaining an accurate picture of energy consumption in public spaces is a critical first step for predicting and enhancing energy efficiency. In practice, such calculations are often complicated, necessitating use of artificial intelligence models which ...
Li-Yuan Chen   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth   +17 more
wiley   +1 more source

Mobile Air Conditioning System Design Study [PDF]

open access: yes, 1993
This study uses a semi-theoretical steady state computer simulation of an automotive air conditioning system to evaluate design options. The simulation has been validated with experimental data.
Zietlow, D.C.   +2 more
core  

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