Results 101 to 110 of about 5,648,704 (342)

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Energy-Efficient Compact Heat Exchangers Made of Porous Heat-Conducting Materials

Известия высших учебных заведений и энергетических объединенний СНГ: Энергетика, 2018
After successful increase of levels of thermal resistances of building enclosing structures, expenses of heat on ventilation of rooms in many cases reached similar magnitudes of indicators of heating in a cold season.
S. N. Osipov, A. V. Zakharenko
doaj   +1 more source

Implementation - More than Monitoring and Enforcement: Evidence from the Implementation of the 1989 Municipal Waste Incineration Directive (89/429/EEC) in Four Member States [PDF]

, 2000
Researchers and policy-makers accept that implementation decisively influences the effectiveness of European (EU) environmental policy. Some Member States lead the development of EU policy and implement Directives with little problem.
Bültman, Alexandra, Eames, Malcolm, Lulofs, Kris, Schucht, Simone   +3 more
core   +2 more sources

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Clothing air gaps in various postures in firefighters' work. [PDF]

Int J Biometeorol, 2023
Psikuta A, Sherif F, Mert E, Mandal S, Annaheim S.   +4 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Closed-Loop Soft Starter Firing Angle Control Method Using Only Current Feedback

IEEE Access
A soft starter is commonly utilized in various industrial induction motor systems to reduce the inrush current during motor startup. The conventional voltage ramp-up method, used in the typical soft starter, gradually increases the voltage over the ...
Dae-Young Yang, Young-Seok Kim, Tae-Ho Oh, Sang-Hoon Lee, Dong-Il Cho   +4 more
doaj   +1 more source

Design and analysis of a novel rotor-segmented axial-field switched reluctance machine

CES Transactions on Electrical Machines and Systems, 2017
As excitation strategy is influenced by the parity of phase number, and serious end effect is caused by full pitch windings adopted by the conventional rotor-segmented switched reluctance machine (RS-SRM), a novel rotor-segmented axial-field switched ...
Wei Sun, Qiang Li, Kai Liu, Lei Li
doaj   +1 more source