Results 51 to 60 of about 3,348,877 (306)

Global air quality and climate

Chemical Society Reviews, 2012
Emissions of air pollutants and their precursors determine regional air quality and can alter climate. Climate change can perturb the long-range transport, chemical processing, and local meteorology that influence air pollution. We review the implications of projected changes in methane (CH4), ozone precursors (O3), and aerosols for climate (expressed ...
Fiore, Arlene, Naik, Vaishali, Spracklen, Dominick, Steiner, Allison, Unger, Nadine, Prather, Michael, Bergmann, Dan, Cameron-Smith, Philip, Cionni, Irene, Collins, William, Dalsøren, Stig, Eyring, Veronika, Folberth, Gerd, Ginoux, Paul, Horowitz, Larry, Josse, Béatrice, Lamarque, Jean-François, Mackenzie, Ian, Nagashima, Tatsuya, O'Connor, Fiona, Righi, Mattia, Rumbold, Steven, Shindell, Drew, Skeie, Ragnhild, Sudo, Kengo, Szopa, Sophie, Takemura, Toshihiko, Zeng, Guang   +27 more
openaire   +8 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Transboundary Air Pollution Transport of PM₁₀ and Benzo[a]pyrene in the Czech–Polish Border Region

Atmosphere, 2022
The article is occupied with the evaluation of the transboundary transport of pollutants in the Czech–Polish border region (between the Moravian-Silesian region and the Silesian Voivodeship) in Central Europe.
Vladimíra Volná, Daniel Hladký, Radim Seibert, Blanka Krejčí   +3 more
doaj   +1 more source

The role of natural variability in projections of climate change impacts on U.S. ozone pollution [PDF]

, 2017
Climate change can impact air quality by altering the atmospheric conditions that determine pollutant concentrations. Over large regions of the U.S., projected changes in climate are expected to favor formation of ground-level ozone and aggravate ...
Garcia-Menendez, F, Monier, E, Selin, NE
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

A model based framework for air quality indices and population risk evaluation, with an application to the analysis of Scottish air quality data [PDF]

, 2013
The paper is devoted to the development of a statistical framework for air quality assessment at the country level and for the evaluation of the ambient population exposure and risk with respect to airborne pollutants.
Banerjee S., Cressie N., Finazzi F., Finazzi F., Shumway R.   +4 more
core   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Ultrafine Particles Monitoring in Paris: From Total Number Concentrations to Size Distributions Measurements

Aerosol and Air Quality Research
Due to their small size and ability to penetrate deeply into the respiratory system, ultrafine particles (UFP) pose a significant health risk. Their concentrations and sources are not consistently monitored and regulated in urban areas, including Paris ...
Grégory Abbou, Véronique Ghersi, François Gaie-Levrel, Anne Kauffmann, Mikael Reynaud, Christophe Debert, Philippe Quénel, Alexia Baudic   +7 more
doaj   +1 more source

Heat waves and human well-being in Madrid (Spain) [PDF]

, 2019
Heat waves pose additional risks to urban spaces because of the additional heat provided by urban heat islands (UHIs) as well as poorer air quality.
Allende, Fernando, Fernández, Felipe, Martilli, Alberto, Rasilla, Domingo   +3 more
core   +3 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source