Results 31 to 40 of about 11,339,588 (238)

Characteristics of school children's personal exposure to ultrafine particles in Heshan, Pearl River Delta, China – A pilot study

Environment International, 2019
Background: There is a significant lack of scientific knowledge on population exposure to ultrafine particles (UFP) in China to date. This paper quantifies and characterises school children's personal UFP exposure and exposure intensity against their ...
Mandana Mazaheri, Weiwei Lin, Samuel Clifford, Dingli Yue, Yuhong Zhai, Muwu Xu, Valeria Rizza, Lidia Morawska   +7 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Characteristics and mixing state of amine-containing particles at a rural site in the Pearl River Delta, China [PDF]

Atmospheric Chemistry and Physics, 2018
Particulate amines play an important role for the particle acidity and hygroscopicity and also contribute to secondary organic aerosol mass. We investigated the sources and mixing states of particulate amines using a single-particle aerosol mass ...
C. Cheng, C. Cheng, Z. Huang, C. K. Chan, Y. Chu, M. Li, M. Li, T. Zhang, Y. Ou, D. Chen, P. Cheng, P. Cheng, L. Li, L. Li, W. Gao, W. Gao, Z. Huang, Z. Huang, B. Huang, B. Huang, B. Huang, Z. Fu, Z. Zhou, Z. Zhou   +23 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Reconstructed VOC emissions reveal hidden ozone precursors: Overlooked roles of primary OVOCs and unmeasured species [PDF]

Atmospheric Chemistry and Physics
Ambient volatile organic compounds (VOCs), including non-methane hydrocarbons (NMHCs) and oxygenated VOCs (OVOCs), are critical precursors of tropospheric ozone (O3).
S. Yin, G. Yang, C. Li, Q. Fu, J. Huo, Y. Fu, R. Yan, L. Yao, L. Wang, L. Wang, L. Wang, L. Wang   +11 more
doaj   +1 more source

Traffic-related air pollution near roadways: discerning local impacts from background [PDF]

Atmospheric Measurement Techniques, 2019
Adverse health outcomes related to exposure to air pollution have gained much attention in recent years, with a particular emphasis on traffic-related pollutants near roadways, where concentrations tend to be most severe.
N. Hilker, J. M. Wang, C.-H. Jeong, R. M. Healy, U. Sofowote, J. Debosz, Y. Su, M. Noble, A. Munoz, G. Doerksen, L. White, C. Audette, D. Herod, J. R. Brook, J. R. Brook, G. J. Evans   +15 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Complexities of peroxyacetyl nitrate photochemistry and its control strategies in contrasting environments in the Pearl River Delta region

npj Climate and Atmospheric Science
Peroxyacetyl nitrate (PAN) is a hazardous secondary pollutant and a nitrogen reservoir in the troposphere, while comprehensive studies on its spatiotemporal distribution, chemical sources, and control strategies are limited.
Tao Liu, Yu Wang, Huang Cai, Hao Wang, Chunlin Zhang, Jun Chen, Yan Dai, Wenlong Zhao, Jiangyong Li, Daocheng Gong, Duohong Chen, Yuhong Zhai, Yan Zhou, Tong Liao, Boguang Wang   +14 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source