Results 81 to 90 of about 1,100,520 (348)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

An IoT enabled system for enhanced air quality monitoring and prediction on the edge

Complex & Intelligent Systems, 2021
Air pollution is a major issue resulting from the excessive use of conventional energy sources in developing countries and worldwide. Particulate Matter less than 2.5 µm in diameter (PM2.5) is the most dangerous air pollutant invading the human ...
Ahmed Samy AbdElAziz Moursi, N. El-Fishawy, S. Djahel, M. Shouman   +3 more
semanticscholar   +1 more source

Urban air quality monitoring using ground-based hyperspectral imaging of vegetation

, 2023
Dobler, GregoryUrban ambient air pollution is not uniformly distributed due to multiple factors that include the range of built and natural surfaces, the diversity and distribution of built structures, the complex interactions between pollutants, and the
Qamar, Farid
core   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Association between air pollution and type II diabetes in Italy from clinical data and population-weighted exposure at the municipality level

Scientific Reports
A growing body of literature supports the association between ambient particulate pollution and the risk of type 2 diabetes (T2DM). Both issues are particularly relevant in Italy.
Cristiana Abbafati, Luciano Nieddu, Giorgio Cattani, Maria Antonietta Reatini, Paola Ponzani   +4 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Time-Dependent Downscaling of PM2.5 Predictions from CAMS Air Quality Models to Urban Monitoring Sites in Budapest

, 2020
Budapest, the capital of Hungary, has been facing serious air pollution episodes in the heating season similar to other metropolises. In the city a dense urban air quality monitoring network is available; however, air quality prediction is still ...
Adrienn Varga-Balogh, Ádám Leelőssy, István Lagzi, Róbert Mészáros   +3 more
core   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Trends in air toxics cancer risk in Southern California, 1998-2018

Environmental Research: Health
Air toxics are an important category of air pollutants that are known to cause adverse health effects, including increased cancer risk. Regulatory efforts at federal, state, and local levels have aimed to decrease air toxics emissions over the past ...
Melissa May Maestas, Scott A Epstein, Nico Schulte, Xiang Li, Xinqiu Zhang, Sang-Mi Lee, Andrea Polidori, Jason Low, Jo Kay Ghosh   +8 more
doaj   +1 more source

Model Evaluation and Uncertainty Analysis of PM2.5 Components over Pearl River Delta Region Using Monte Carlo Simulations

Aerosol and Air Quality Research, 2020
Sulfate, nitrate, ammonium, organic carbon (OC) and black carbon (BC) are the key components of PM2.5, but predicting their concentrations remains a challenge because of high uncertainties in the modeling.
Qian Wu, Xiao Tang, Lei Kong, Zirui Liu, Duohong Chen, Miaomiao Lu, Huangjian Wu, Jin Shen, Lin Wu, Xiaole Pan, Jie Li, Jiang Zhu, Zifa Wang   +12 more
doaj   +1 more source