Results 61 to 70 of about 3,007,199 (350)

Risk Assessment of Freezing–Thawing Hazards in the Daxing’anling Forest Region

Atmosphere, 2023
The Daxing’anling forest region represents a crucial forestry hub in China and confronts some of the nation’s most severe freezing–thawing hazards. This study delved into the temporal trends and spatial distributions of various parameters related to ...
Kezheng Chen, Shuai Huang
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

The Air-temperature Response to Green/blue-infrastructure Evaluation Tool (TARGET v1.0) : an efficient and user-friendly model of city cooling [PDF]

, 2019
The adverse impacts of urban heat and global climate change are leading policymakers to consider green and blue infrastructure (GBI) for heat mitigation benefits.
Broadbent, Ashley M, Coutts, Andrew M, Demuzere, Matthias, Krayenhoff, E Scott, Nice, Kerry A, Tapper, Nigel J, Wouters, Hendrik   +6 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Effect of Evaporator Outflow Rate on Air Distribution in the Computer Laboratory using CFD

International Journal of Electrical, Energy and Power System Engineering, 2020
The ideal room temperature will create comfort in the learning and teaching process. With increasing outdoor air temperature due to climate change, an air conditioner is needed to reach the ideal room temperature. An air conditioner is an air conditioner
Rosyida Permatasari, Martinus Bambang Susetyarto   +1 more
doaj   +1 more source

Pollutant dispersion in a developing valley cold-air pool [PDF]

, 2015
Pollutants are trapped and accumulate within cold-air pools, thereby affecting air quality. A numerical model is used to quantify the role of cold-air-pooling processes in the dispersion of air pollution in a developing cold-air pool within an alpine ...
A Gohm, A Scotti, BA Burkholder, C Brulfert, CD Whiteman, CD Whiteman, CD Whiteman, CD Whiteman, CH Moeng, Charles Chemel, CJ Nappo, D Martínez, D Martínez, D Zardi, F Chen, F Harnisch, GB Raga, GD Silcox, I Vergeiner, J Cuxart, J Cuxart, J Cuxart, J Dudhia, JA Businger, JA King, JB Klemp, JW Deardorff, KR Baker, L Mahrt, L Mahrt, M Dorninger, M Franceschi de, M Lehner, P Burns, PA Jiménez, Paul Burns, PC Manins, PG Baines, SB Vosper, SB Vosper, SM Lee, SW Hoch, T Haiden, T Kitada, TB McKee, TH Ellison, Y Mahrer   +46 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

FEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso, Jaime Hiniesta‐Valero, Alejandra Guerra‐Castellano, Miguel A. De la Rosa, Irene Díaz‐Moreno   +4 more
wiley   +1 more source

A validated methodology for the prediction of heating and cooling energy demand for buildings within the Urban Heat Island: Case-study of London [PDF]

, 2010
This is the post-print version of the final paper published in Solar Energy. The published article is available from the link below. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and ...
Anna Mavrogianni, Ben Croxford, Erell, Giridharan, Kim, Kolokotroni, Kolokotroni, Kolokotroni, Livada, Maria Kolokotroni, Memon, Michael Davies, Mihalakakou, Mihalakakou, Oke, Oke, Roth, Saiful Bhuiyan, Swaid, Tabahashi, Taha, Taha, Watkins   +22 more
core   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source