Results 61 to 70 of about 3,003,880 (282)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Method and apparatus for checking fire detectors [PDF]

open access: yes, 1974
A fire detector checking method and device are disclosed for nondestructively verifying the operation of installed fire detectors of the type which operate on the principle of detecting the rate of temperature rise of the ambient air to sound an alarm ...
Clawson, G. T.
core   +1 more source

Pollutant dispersion in a developing valley cold-air pool [PDF]

open access: yes, 2015
Pollutants are trapped and accumulate within cold-air pools, thereby affecting air quality. A numerical model is used to quantify the role of cold-air-pooling processes in the dispersion of air pollution in a developing cold-air pool within an alpine ...
A Gohm   +46 more
core   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

open access: yesFEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee   +6 more
wiley   +1 more source

Experimental Design and Research of Air Spring Low Temperature Properties

open access: yes机车电传动, 2019
Low temperature test on the air spring is an important means for improving alpine EMUs bogie dynamic performance. Low temperature working condition of air spring was analyzed briefly, and air spring full two-dimensional load testing scheme at low ...
Liqun PENG   +3 more
doaj  

Apparatus for supplying conditioned air at a substantially constant temperature and humidity [PDF]

open access: yes, 1980
The apparatus includes a supply duct coupled to a source of supply air for carrying the supply air therethrough. A return duct is coupled to the supply duct for carrying return conditioned air therethrough. A temperature reducing device is coupled to the
Obler, H. D.
core   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

open access: yesFEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento   +6 more
wiley   +1 more source

Comparison of air temperature measured in a vineyard canopy and at a standard weather station.

open access: yesPLoS ONE, 2020
The complex environment within a crop canopy leads to a high variability of the air temperature within the canopy, and, therefore, air temperature measured at a weather station (WS) does not represent the internal energy within a crop.
Andrés Javier Peña Quiñones   +4 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Dynamics and Modern Temperature Regime of Calendar Summer over Stavropol Height

open access: yesНаука. Инновации. Технологии, 2022
Introduction. The article is devoted to calculation and analysis dynamics and modern temperature regime of calendar summer of over Stavropol height, which is one the main ground features of the Central Pre-Caucasus.
V. I. Volkova   +3 more
doaj  

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