Results 21 to 30 of about 72,988 (218)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
FEBS Open Bio, EarlyView.Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Advanced Engineering Materials, EarlyView.This article presents the design, modeling, and characterization of air‐pressure–actuated programmable vibroacoustic metamaterials (PVAMM). The study focuses on leveraging air pressure to dynamically tune resonance frequencies for effective noise attenuation.
William Kaal +2 more
wiley +1 more source
Volcanic Ash Region Path Planning Based on Improved A-Star Algorithm
Journal of Advanced Transportation, 2022 In civil aviation flight path planning, in order to effectively reduce the safety threat caused by the volcanic ash area to the civil aviation flight, factors such as the speed and acceleration of the aircraft in the volcanic ash area must be considered.
Lan Ma +3 more
doaj +1 more source
Nano‐Scale Characterization of Impurities Segregation in Solid Oxide Electrolysis Cells
Advanced Functional Materials, EarlyView.Cathodic polarization induces impurity segregation in Ni, forming an amorphous Na─Al─Si─O amorphous phase at grain boundaries. Under ultralow oxygen partial pressure, multiple elements dissolve, migrate, and reoxidize within the metal. A patterned model system provides direct nanoscale evidence, clarifying the mechanism of polarization‐driven impurity ...
Zhongtao Ma +5 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.This study investigates the M13 bacteriophage as a biomimetic nanovector capable of crossing in vitro models of the blood–brain barrier. By exploiting peculiar transcellular pathways, M13 avoids lysosomal degradation and preserves its structural integrity and functionality.
Silvia Vercellino +12 more
wiley +1 more source
Journal of Advanced TransportationFlight turbulence poses a severe threat to aviation safety, and achieving its effective early warning is a critical challenge to be addressed. To overcome the limitations of traditional methods reliant on single information sources or advanced remote ...
Hongyong Wang +3 more
doaj +1 more source
Optimal Sensor Deployment and Velocity Configuration With Hybrid TDOA and FDOA Measurements
IEEE Access, 2019 Source localization based on the hybrid time-difference-of-arrival (TDOA) and frequency-difference-of-arrival (FDOA) measurements from distributed sensors is an essential problem in wireless sensor networks (WSNs).
Weijia Wang +4 more
doaj +1 more source
Time cooperative path planning for unmanned marine system
Zhongguo Jianchuan Yanjiu, 2022 ObjectiveIn order to solve the problem of time cooperative path planning for unmanned marine system (UMS) in complex environments, we propose a cooperative path planning method based on a differential evolution (DE) algorithm.
Fengchuan YIN +5 more
doaj +1 more source