Results 41 to 50 of about 12,457,896 (279)

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

Advanced Science, EarlyView.
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim, Minju Lee, Yiming Wang, Eunjin Choi, Ji Sun Park, Kyungmin Park, Hayoung Jeon, Donghyun Kim, Donghyun Lee, Yeeun Lee, Kee‐Pyo Kim, Eunha Kim, Heebeom Koo   +12 more
wiley   +1 more source

Detection of Low-Altitude Unmanned Vehicle and Flying Bird by Improved YOLOv7

International Journal of Aerospace Engineering
With the rapid development of low-altitude economy and unmanned aerial vehicle (UAV) technologies, reliable UAV surveillance has become increasingly important for aviation safety and low-altitude airspace management. However, accurate recognition of UAVs
Weiyu Xie, Qiang Zhang, Tanwuguo Chen
doaj   +1 more source

Analysis of the Relationship between Upper-Level Aircraft Turbulence and the East Asian Westerly Jet Stream

Atmosphere
The jet stream is a primary factor contributing to turbulence, especially for upper-level aircraft. This study utilized pilot reports and ERA5 data from 2023 to investigate the relationship between upper-level turbulence and the East Asian westerly jet ...
Kenan Li, Xi Chen, Liman A, Kaijun Wu, Haiwen Liu, Fengjing Dai, Tiantian Yang, Jia Yu, Kehua Wang   +8 more
doaj   +1 more source

Speech GAU: A Single Head Attention for Mandarin Speech Recognition for Air Traffic Control

Aerospace, 2022
The rise of end-to-end (E2E) speech recognition technology in recent years has overturned the design pattern of cascading multiple subtasks in classical speech recognition and achieved direct mapping of speech input signals to text labels. In this study,
Shiyu Zhang, Jianguo Kong, Chao Chen, Yabin Li, Haijun Liang   +4 more
doaj   +1 more source

A Dual‐Membrane Biomimetic Nanoplatform Enables Triple‐Modal Therapy Against SARS‐CoV‐2 Through Viral Decoy, Inflammation Neutralizing, and Intracellular RNAi

Advanced Science, EarlyView.
[A&T]MLN is a triple‐modal nanoplatform with siRNA‐loaded LN coated with hybrid ACE2/macrophage membrane. It blocks viral entry, neutralizes IL‐6/IL‐1β/TNF‐α, and delivers siRNA to suppress viral replication. In a murine lung injury model, it attenuates inflammation, offering a multi‐pronged strategy against SARS‐CoV‐2 variants and hyperinflammation ...
Hui Li, Bohan Zhang, Chao Shang, Yi Li, Te Zhao, Shengya Liu, Dan Liu, Junwei Che, Cuiling Zhang, Pinghui Wu, Wenjie Yang, Junjie Ding, Yuhua Ran, Yanan Zhai, Haihua Xiao, Jing Gao, Xiao Li, Chunsheng Gao, Lin Li, Zhiping Li   +19 more
wiley   +1 more source

Dynamic Aircraft Wake Separation Based on Velocity Change

Aerospace, 2022
Traditional research on static wake-vortex reduction usually considers only the influence of external environmental factors, while ignoring the dynamic change in an aircraft’s flight state.
Weijun Pan, Zirui Yin, Yuming Luo, Anding Wang, Yuanjing Huang   +4 more
doaj   +1 more source

Formulating the cognitive design problem of air traffic management [PDF]

, 1998
Evolutionary approaches to cognitive design in the air traffic management (ATM) system can be attributed with a history of delayed developments. This issue is well illustrated in the case of the flight progress strip where attempts to design a computer ...
Dowell, J., John Dowell
core  

Targeted‐Penetrating Biomimetic Hybrid Transfersomes for Enhanced Transdermal Gene Transfection in Hypertrophic Scar Therapy

Advanced Science, EarlyView.
Hypertrophic scar fibroblasts membrane‐hybridized cationic transfersomes enable efficient loading and transdermal delivery of TGF‐β1 siRNA through multiple skin penetration pathways. The biomimetic platform enhances homotypic targeting, transfection, and immune evasion, suppresses TGF‐β1‐driven fibrotic signaling, and reduces extracellular matrix ...
Hui Xing, Ziyi Zhao, Yuhui Yang, Yichen Lin, Yinglin Xuan, Ziyang Wang, Kai Lv, Xiaoxu Zhu, Zhi Zhang, Dong Ma   +9 more
wiley   +1 more source

EphB1 Receptor Blockade Augments Morphine Antinociception via Inhibiting GRK2‐Mediated µ‐Opioid Receptor Internalization

Advanced Science, EarlyView.
Administration of opioids activates ephrinB2‐EphB1 receptor signaling. Activated EphB1 receptors induce GRK2‐mediated phosphorylation of MOR at Ser375, which initiates the internalization of MOR and reduces opioid antinociception at the behavioral level. ABSTRACT Opioids are the primary treatment for severe pain in clinical practice.
Bo Peng, Xiaqing Lin, Hongyu Yao, Cheng Li, Huabao Liao, Yuexin Liu, Boxu Cao, Xue‑Jun Song   +7 more
wiley   +1 more source

Hybrid Spring‐Coupled Broadband Energy Harvester Integrated with CuSCN Functionalized Triboelectric Vibration Sensor for Self‐Sustainable Vehicular IoTs

Advanced Science, EarlyView.
A self‐sustainable vehicular vibration and indoor environment monitoring IoT platform is developed which integrates a hybrid spring‐coupled broadband energy harvester with a machine learning‐assisted PAN‐CuSCN nanofiber triboelectric vibration sensor for subtle‐to‐wide‐range vibration detection and road/speed classification.
Trilochan Bhatta, Gagan Bahadur Pradhan, Shital Sharma, MoonSeong Jo, Aklesh Teli, Hochan Chang, Jae Yeong Park   +6 more
wiley   +1 more source