Results 211 to 220 of about 107,900 (317)

Aire and Fezf2 Shape the Medullary Thymic Epithelial Cell Immunopeptidome for Central Tolerance

open access: yesImmunology, EarlyView.
Central tolerance is shaped not merely by promiscuous gene expression in medullary thymic epithelial cells (mTECs), but by the subset of self‐peptides ultimately presented on MHC class II molecules. We propose a multilayered framework in which AIRE/Aire and FEZF2/Fezf2, together with specialised differentiation programmes—including thymic mimetic‐cell ...
Geraldo Aleixo Passos   +5 more
wiley   +1 more source

Case Report: Clinical and molecular features of a radiosensitive autoimmune polyendocrine syndrome type 1 patient with oral carcinoma. [PDF]

open access: yesFront Genet
Chikhaoui A   +6 more
europepmc   +1 more source

Anticipated Stigma in Nursing: A Concept Analysis Informed by Cannabis Use Disclosure

open access: yesJournal of Advanced Nursing, EarlyView.
ABSTRACT Aim To clarify the concept of anticipated stigma and examine its relevance to cannabis use disclosure in nursing using an evolutionary concept analysis approach. Design Concept analysis guided by Rodgers and Knafl's evolutionary method. Data Sources An interdisciplinary purposive literature review was conducted using empirical and theoretical ...
Daniel D. King
wiley   +1 more source

Household costs of care in children under five attending primary care in Burkina Faso, Guinea, Mali and Niger: a cross-sectional study nested in the AIRE project. [PDF]

open access: yesBMJ Glob Health
Agbeci H   +23 more
europepmc   +1 more source

Mapping malignant T‐cell states and immune circuits in Sézary syndrome by single‐cell analysis

open access: yesJournal of the European Academy of Dermatology and Venereology, EarlyView.
Peripheral blood single‐cell RNA‐seq from leukaemic CTCL defined three malignant T‐cell programmes: MTC CM, MTC Reg and MTC E/EM, each with distinct features and candidate vulnerabilities. For example, inferred immune circuits highlighted actionable IL‐10/JAK–TYK2–STAT3 signalling, KIR–MHC I inhibitory interactions and myeloid/B‐cell inflammatory and ...
Beth A. Childs   +6 more
wiley   +1 more source

Prevalence and factors associated with severe illness in West African children under 5 years of age detected with routine pulse oximetry in primary care. [PDF]

open access: yesBMJ Glob Health
Hedible KGB   +19 more
europepmc   +1 more source

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