Results 141 to 150 of about 294,177 (307)

Intravenous lanadelumab for the treatment of moderately ill COVID‐19 patients

British Journal of Clinical Pharmacology, EarlyView.
Aims Kallikrein‐kinin system (KKS) dysregulation is hypothesized to play a pathogenetic role in COVID‐19‐associated pulmonary oedema. To investigate the efficacy and safety of intravenous lanadelumab, a monoclonal antibody that inhibits plasma kallikrein, in COVID‐19, we conducted a phase 2, open‐label, randomized‐controlled, proof‐of‐concept ...
Job J. Engel, Christine van Linge, W. Joost Wiersinga, Ilse J. E. Kouijzer, Quirijn de Mast, Robert‐Jan Hassing, Danique J. H. Huijbens, Helen L. Leavis, Roger Schutgens, Coen Maas, Kit C. B. Roes, Frank L. van de Veerdonk, Roger Brüggemann   +12 more
wiley   +1 more source

Air Quality Index Association With Cytokine Inflammatory Markers in Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
Nanda Nayak, Christina Dorismond, Rory Lubner, Daniel Lofgren, Ping Li, Katherine Cahill, Mason Krysinski, Rakesh Chandra, Justin Turner, Naweed Chowdhury   +9 more
wiley   +1 more source

Analysis of interstitial lung disease in pharmacovigilance databases: Coding challenges and interpretation biases—An update

British Journal of Clinical Pharmacology, EarlyView.
Aim Clinically, interstitial lung disease (ILD) is a heterogeneous group of respiratory disorders. Due to their low incidence, pharmacovigilance database analysis is useful to detect them. Precise diagnosis is challenging as well as coding in these databases. Query criteria are among the key elements for a good signal detection.
Romane Freppel, Adeline Benis, Philippe Bonniaud, Jean‐Luc Faillie, Aurélie Grandvuillemin   +4 more
wiley   +1 more source

Management of airway mucus hypersecretion in chronic airway inflammatory disease: Chinese expert consensus (English edition)

International Journal of COPD, 2018
Yongchun Shen,1 Shaoguang Huang,2 Jian Kang,3 Jiangtao Lin,4 Kefang Lai,5 Yongchang Sun,6 Wei Xiao,7 Lan Yang,8 Wanzhen Yao,6 Shaoxi Cai,9 Kewu Huang,10 Fuqiang Wen1 1Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan ...
Shen Y, Huang S, Kang J, Lin J, Lai K, Sun Y, Xiao W, Yang L, Yao W, Cai S, Huang K, Wen F   +11 more
doaj  

Medical versus science students: Knowledge, perceptions and learning of core pharmacology concepts

British Journal of Clinical Pharmacology, EarlyView.
Aims Pharmacology is a core discipline underpinning both medical and biomedical science education, essential for understanding drug action, safety and therapeutic efficacy. This study compared pharmacology knowledge, perceptions and learning experiences between second‐year medical and science students to evaluate how effectively each curriculum ...
Zina Alfahl, Rachel Lynch, Cara O'Dwyer, John P. Kelly   +3 more
wiley   +1 more source

Adaptive Machine Learning Framework for Optimizing the Affinity Purification of Adeno‐Associated Viral Vectors

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Adeno‐associated viral (AAV) vectors for gene therapy are becoming integral to modern medicine, providing therapeutic options for diseases once deemed incurable. Currently, viral vector purification is a critical bottleneck in the gene therapy industry, impacting product efficacy and safety as well as accessibility and cost to patients ...
Kelvin P. Idanwekhai, Shriarjun Shastry, Morgan R. Hurst, Arianna Minzoni, Eduardo Barbieri, Luke Remmler, Eugene N. Muratov, Michael A. Daniele, Stefano Menegatti, Alexander Tropsha   +9 more
wiley   +1 more source

Comprehensive Nursing Management of Anticoagulation and Heart Failure Surveillance in a Chinese Patient With Mirror‐Image Dextrocardia Post‐MitraClip Surgery: A First Case Report

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Mitral regurgitation (MR) is the valent type of valvular heart disease, caused by primary leaflet lesions or annular dilatation secondary to left ventricular dysfunction. It can lead to a series of complications such as volume overload, exacerbated pulmonary congestion, and heart failure, significantly impacting patient prognosis ...
Juelian Li, Chun Wu, Chao Shang, Yu Deng, Jinxia Zhang   +4 more
wiley   +1 more source

How to Reduce Wheat Allergens and FODMAPs in Foods: A Critical Review of Patents

Cereal Chemistry, EarlyView.
ABSTRACT Background and Objectives Supported by scientific evidence, this critical review of the patent literature examined methods to reduce wheat allergens and FODMAPs in foods, which may trigger digestive disorders and other health problems. The following topics were covered: proteolytic enzymes, proteolytic bacteria and yeasts, separation, plant ...
Pierre Gélinas, Jérémie Théolier
wiley   +1 more source

Anti‐Obesity Pharmacotherapy and Emerging Multimodal Interventions for Obstructive Sleep Apnea

Chronic Diseases and Translational Medicine, EarlyView.
Cellular and molecular mechanisms of obesity‐related obstructive sleep apnea (OSA). ADMA: asymmetric dimethyrarginine, NLRP3: nucleotide‐binding domain, leucine‐rich repeat family, Pyrin domain containing 3, TLR: toll‐like receptors, IL‐1β: interleukin‐1β, IL‐6: interleukin‐6; LPS: lipopolysacharide, ROS: reactive oxygen species, TNF‐α.
Anish Preshy, Cornelius J. Fernandez, Mohammad Hamid Nedai, Joseph M. Pappachan   +3 more
wiley   +1 more source

Successful airway management with King Vision device in a child with Morquio syndrome: case report

Revista de la Facultad de Ciencias de la Salud, 2017
Morquio syndrome also called type IV mucopolysaccharidosis, is a condition produced by lysosomal deposit. Morquio syndrome have several implications in the airway management because is characterized by C1-C2, instability, short height, cervical spine ...
Lina Maritza Guerra, Mario Andrés Zamudio, Jonny Arbey Salazar   +2 more
doaj