Results 111 to 120 of about 15,388 (248)

The role of the respiratory tract microbiome in respiratory health

Лечащий Врач, 2021
The proposed review summarizes recent advances in the study of respiratory microbiota, the relationship between the upper respiratory tract microbiome and the lung, and a discussion of the possible mechanisms of influence of the microbiome on asthma and ...
N. G. Astafieva, D. Yu. Kobzev, I. V. Gamova, I. A. Perfilova, E. N. Udovichenko, L. V. Skuchaeva, I. E. Michailova   +6 more
doaj  

The lower airway microbiome in paediatric health and chronic disease [PDF]

The advent of next generation sequencing has rapidly challenged the paediatric respiratory physician’s understanding of lung microbiology and the role of the lung microbiome in host health and disease.
Langley, R J, Hansen, R; id_orcid, Gerasimidis, K., Campbell, S., Hansen, R., Dicker, A J; id_orcid, Langley, R.J., Milling, S, Dicker, A.J., Campbell, S, Gerasimidis, K, Milling, S.   +11 more
core   +1 more source

Ultra‐Processed Food Consumption and Childhood Allergic Diseases: Increased Risk of Asthma Onset in the SENDO Project

Allergy, EarlyView.
The SENDO cohort study (2015–2024) prospectively analyzed the impact of ultra‐processed food (UPF) consumption on asthma and atopy in 1,546 Spanish children. Higher UPF intake (NOVA 4 classification) was significantly associated with an increased risk of asthma but not atopy, atopic dermatitis, neumoallergen sensitation, food allergy over five years ...
O. Galindo, M. J. Goikoetxea, L. Moreno‐Galarraga, L. Argiz, J. M. Moreno‐Villares, Victor de la O, N. Martín‐Calvo   +6 more
wiley   +1 more source

Inflammation-driven periostin in ECRS has contrasting effects on tissue structural integrity and osteitis

Frontiers in Immunology
IntroductionEosinophilic chronic rhinosinusitis (ECRS) is a severe form of chronic rhinosinusitis characterized by type 2 inflammation, tissue remodeling, and bone thickening, known as osteitis.
Soo-In Kim, Soo-In Kim, Soo-In Kim, Min-Seok Rha, Min-Seok Rha, Min-Seok Rha, Jinsun Kim, Sang Hyeon Ahn, Sang Hyeon Ahn, Ji-Hwan Ryu, Ji-Hwan Ryu, Ji-Hwan Ryu, Hyung-Ju Cho, Hyung-Ju Cho, Chang-Hoon Kim, Chang-Hoon Kim, Chang-Hoon Kim   +16 more
doaj   +1 more source

Diet–Microbiome–Immune Interactions at the Gut Mucosa in Food Allergy: Mechanisms, Gaps, and Therapeutic Implications

Allergy, EarlyView.
ABSTRACT Mucosal surfaces are sites of highly dynamic interactions among epithelial and immune cells, environmental exposures, particularly dietary inputs, and the diverse microbial communities and their metabolites. These elements continually influence each other to maintain homeostasis and ensure appropriate immune discrimination between pathogens ...
Clara Delaroque, Liam O'Mahony, Inge Kortekaas Krohn, Charlotte G. Mortz, Markus Ollert, Mahesh S. Desai   +5 more
wiley   +1 more source

Vitamin D and allergic airway disease shape the murine lung microbiome in a sex-specific manner [PDF]

, 2016
BACKGROUND: Vitamin D is under scrutiny as a potential regulator of the development of respiratory diseases characterised by chronic lung inflammation, including asthma and chronic obstructive pulmonary disease. It has anti-inflammatory effects; however,
Gorman, S, Michael Roggenbuck, Barfod, Kenneth Klingenberg, Geldenhuys, Sian, Sørensen, Søren J., Feelisch, Martin, Prue H. Hart, Shelley Gorman, Anderson, Denise, Martin Feelisch, Hart, PH, Denise Anderson, Sørensen, Søren Johannes, Gorman, Shelley, Roggenbuck, Michael, Barfod, KK, Kenneth Klingenberg Barfod, Roggenbuck, M, Anderson, D, Feelisch, M, Weeden, Clare E., Hart, Prue H., Sørensen, SJ, Sian Geldenhuys, Søren J. Sørensen, Clare E. Weeden, Weeden, CE, Geldenhuys, S   +27 more
core   +1 more source

Immune System Development—Pro Tips for Paediatricians

Acta Paediatrica, EarlyView.
ABSTRACT There are many misconceptions about the immune system in children, its impact on infectious disease susceptibility and its role in the rapidly increasing rates of immune mediated diseases in industrialized societies. In this mini review, I will discuss common believes and the data supporting or countering such believes, with a focus on ...
Petter Brodin
wiley   +1 more source

Tobacco use, self-reported professional dental cleaning habits, and lung adenocarcinoma diagnosis are associated with bronchial and lung microbiome alpha diversity

Respiratory Research
Rationale The lung microbiome is an inflammatory stimulus whose role in the development of lung malignancies is incompletely understood. We hypothesized that the lung microbiome associates with multiple clinical factors, including the presence of a lung ...
Alexa A. Pragman, Shane W. Hodgson, Tianhua Wu, Allison Zank, Rosemary F. Kelly, Cavan S. Reilly, Chris H. Wendt   +6 more
doaj   +1 more source

Emerging Paediatric Uses of Dupilumab Beyond Approvals

Clinical &Experimental Allergy, EarlyView.
Dupilumab, through IL‐4Rα blockade, shows promising efficacy beyond approved indications in paediatric diseases driven by T2 inflammation. Emerging evidence—mainly from small studies—supports improvements in disease severity and quality of life, highlighting its potential as a targeted, steroid‐sparing therapy while underscoring the need for ...
Simone Foti Randazzese, Anna Calamita, Diletta D'Angelo, Alessia Marseglia, Esther Mesa Lombardero, Sara Pedersoli, Micol Tedeschi, Mara De Amici, Sara Manti, Valeria Brazzelli, Amelia Licari, Gian Luigi Marseglia   +11 more
wiley   +1 more source

The effect of influenza virus on the human oropharyngeal microbiome

, 2018
© The Author(s) 2018. Background. Secondary bacterial infections are an important cause of morbidity and mortality associated with influenza infections. As bacterial disease can be caused by a disturbance of the host microbiome, we examined the impact of
Wade, WG, Wade, William G., Ramos-Sevillano, Elisa, Tang, Christoph M, Tang, Christoph M., Wade, W, Mann, Alex, Killingley, B, Nguyen-Van-Tam, JS, Tang, CM, Wade, William G, Gilbert, A, Lambkin-Williams, Robert, Ramos-Sevillano, E, Killingley, Ben, Tang, Christoph, Gilbert, Anthony, Lambkin-Williams, R, Nguyen-Van-Tam, Jonathan S, Mann, A   +19 more
core   +1 more source