Results 111 to 120 of about 166,653 (343)

Clinical Significance of Bronchodilator Responsiveness Evaluated by Forced Vital Capacity in COPD: SPIROMICS Cohort Analysis. [PDF]

, 2019
ObjectiveBronchodilator responsiveness (BDR) is prevalent in COPD, but its clinical implications remain unclear. We explored the significance of BDR, defined by post-bronchodilator change in FEV1 (BDRFEV1) as a measure reflecting the change in flow and ...
Anderson, Wayne, Arjomandi, Mehrdad, Barjaktarevic, Igor Z, Bhakta, Nirav R, Bhatt, Surya P, Bowler, Russell, Buhr, Russell G, Christenson, Stephanie A, Cooper, Christopher B, Couper, David, Criner, Gerard, Curtis, Jeffrey L, Doerschuk, Claire M, Dransfield, Mark T, Drummond, M Bradley, Han, MeiLan K, Hansel, Nadia, Hoffman, Eric A, Hu, Scott, Kaner, Robert J, Kanner, Richard E, Kim, Victor, Krishnan, Jerry A, Martinez, Fernando J, NHLBI SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS), O'Neal, Wanda K, Ortega, Victor E, Paine Iii, Robert, Peters, Stephen P, Pirozzi, Cheryl S, Ronish, Bonnie, Tashkin, Donald P, Wang, Xiaoyan, Wells, James Michael, Woodruff, Prescott G   +34 more
core   +2 more sources

RIPK1 Drives JAK1‐STAT3 Signaling to Promote CXCL1‐Mediated Neutrophil Recruitment in Sepsis‐Induced Lung Injury

Advanced Science, EarlyView.
This article examines the central role of RIPK1 in the pathogenesis of sepsis‐induced lung injury. It elucidates how RIPK1 initiates an inflammatory cascade by activating JAK1‐STAT3 signaling, leading to CXCL1‐mediated neutrophil infiltration. Importantly, it demonstrates that pharmacological inhibition of RIPK1 effectively attenuates inflammation and ...
Hao Sun, Xiya Li, Shenjia Gao, Yi Jiang, Xinyi Wu, Zhaoyuan Chen, Han Wu, Qing Hua, Rui Zu, Huaijiang Xiang, Ronen Ben‐Ami, Changhong Miao, Li Tan, Ying Li, Jun Wang, Wankun Chen   +15 more
wiley   +1 more source

Prevalence and severity of airway obstruction in an Italian adult population

Monaldi Archives for Chest Disease, 2005
Background. This study sets out to estimate the prevalence and the degree of severity of bronchial obstruction in an adult population with three different diagnostic criteria: the European Respiratory Society (ERS), the American Thoracic Society (ATS ...
G. Riccioni, M. De Benedictis, R. Della Vecchia, C. Di Ilio, M.T. Guagnano, N. D’Orazio   +5 more
doaj   +1 more source

Forced Expiratory Time: A Simple Test for Airways Obstruction [PDF]

, 1964
S. Lal, Angella D. Ferguson, E. J. M. Campbell   +2 more
openalex   +1 more source

Homocysteine Exacerbates Pulmonary Fibrosis via Orchestrating Syntaxin 17 Homocysteinylation of Alveolar Type II Cells

Advanced Science, EarlyView.
The study identifies elevated homocysteine (Hcy) levels in idiopathic pulmonary fibrosis patients' samples, with alveolar type 2 cells as the primary site of Hcy metabolism. Methionine synthase reductase downregulation in these cells exacerbates fibrosis, while folate administration reduces Hcy levels and alleviates fibrosis.
Jiefeng Huang, Ke Fang, Wuyan Lu, Rongrong Wu, Yuanyuan Chen, Linxiao Li, Zihao Hu, Zixin Cai, Yu Jiang, Xinli Fan, Jinyi Deng, Guangpeng Liu, Zhuang Luo, Lei Cui, Shuaijun Li   +14 more
wiley   +1 more source

Prenatal detection of congenital high airway obstruction syndrome with encephalocele

Indian Journal of Radiology and Imaging, 2016
Congenital high airway obstruction syndrome (CHAOS) causes secondary morphological changes which can be detected on ultrasound. Here we report a case of congenital high airway obstruction with an occipital encephalocele detected at 23 weeks of gestation.
Laxmi Devi Padmanabhan, Sheela Nampoothiri   +1 more
doaj   +1 more source

Differentiation Between Localized and Generalized Airway Obstruction [PDF]

, 1964
Bo Simonsson, R Malmberg
openalex   +1 more source

Metabolic Interplay in Acute Lung Injury: PARK7 Integrates FADS1/2‐Dependent PUFA Metabolism and H3K14 Lactylation to Attenuate Endothelial Ferroptosis and Dysfunction

Advanced Science, EarlyView.
SCAP/ARDS patients show reduced unsaturated fatty acids (UFAs) but higher PARK7 and lactate in plasma. PARK7 correlates positively with lactate and negatively with UFAs. Pulmonary endothelial cell multi‐omics show FADS1/2 downregulation and impaired PUFA metabolism. Lactate boosts PARK7 via H3K14 lactylation, and PARK7 then restores FADS1/2.
Jian Xu, Yuhan Wang, Weiqi Mao, Tianchang Wei, Yufan Li, Juan Song, Cuiping Zhang, Xiaoyan Chen, Cuicui Chen, Qingyuan Xu, Xu Wu, Yuanlin Song   +11 more
wiley   +1 more source

Rapid Onset Acute Epiglottitis Leading to Negative Pressure Pulmonary Edema

Indian Journal of Anaesthesia, 2007
Pulmonary edema is a potentially life-threatening complication of acute airway obstruction. It develops rapidly, without warning, in young healthy individuals.
V Saraswat, P V Madhu, Suresh S Kumar
doaj  

Bronchodilator response patterns in patients with chronic airways obstruction: use of peak inspiratory flow rate. [PDF]

, 1967
K.B. Saunders
openalex   +1 more source