Results 1 to 10 of about 754,493 (312)

TGF-β1 Activates Nasal Fibroblasts through the Induction of Endoplasmic Reticulum Stress

Biomolecules, 2020
(1) Background: Tissue remodeling and extracellular matrix (ECM) accumulation contribute to the development of chronic inflammatory diseases of the upper airway.
Jae-Min Shin, Ju-Hyung Kang, Joo-Hoo Park, Hyun-Woo Yang, Heung-Man Lee, Il-Ho Park   +5 more
doaj   +1 more source

Lower airway dysbiosis affects lung cancer progression

Cancer Discovery, 2020
In lung cancer, enrichment of the lower airway microbiota with oral commensals commonly occurs and ex vivo models support that some of these bacteria can trigger host transcriptomic signatures associated with carcinogenesis. Here, we show that this lower
Jun-Chieh J. Tsay, Benjamin G. Wu, I. Sulaiman, K. Gershner, R. Schluger, Yonghua Li, T. Yie, P. Meyn, E. Olsen, L. Perez, B. Franca, J. Carpenito, T. Iizumi, M. El-Ashmawy, M. Badri, J. Morton, N. Shen, Linchen He, G. Michaud, S. Rafeq, J. Bessich, Robert L. Smith, H. Sauthoff, K. Felner, R. Pillai, Anastasia-Maria Zavitsanou, Sergei B Koralov, V. Mezzano, C. Loomis, A. Moreira, W. Moore, A. Tsirigos, A. Heguy, W. Rom, D. Sterman, H. Pass, J. Clemente, Huilin Li, Richard Bonneau, Kwok-kin Wong, T. Papagiannakopoulos, L. Segal   +41 more
semanticscholar   +1 more source

Airway Remodeling in Asthma

Frontiers in Medicine, 2020
Asthma is an inflammatory disease of the airways that may result from exposure to allergens or other environmental irritants, resulting in bronchoconstriction, wheezing, and shortness of breath.
Kenneth P. Hough, M. Curtiss, Trevor J Blain, Rui-Ming Liu, J. Trevor, J. Deshane, V. Thannickal   +6 more
semanticscholar   +1 more source

A revised airway epithelial hierarchy includes CFTR-expressing ionocytes

Nature, 2018
The airways of the lung are the primary sites of disease in asthma and cystic fibrosis. Here we study the cellular composition and hierarchy of the mouse tracheal epithelium by single-cell RNA-sequencing (scRNA-seq) and in vivo lineage tracing.
Daniel T. Montoro, Adam L. Haber, Moshe Biton, V. Vinarský, B. Lin, S. Birket, F. Yuan, Sijia Chen, H. Leung, Jorge Villoria, Noga Rogel, Grace Burgin, Alexander M. Tsankov, Avinash Waghray, M. Slyper, Julia Waldman, Lan Nguyen, Danielle Dionne, O. Rozenblatt-Rosen, P. Tata, H. Mou, M. Shivaraju, H. Bihler, M. Mense, G. Tearney, S. Rowe, J. Engelhardt, A. Regev, J. Rajagopal   +28 more
semanticscholar   +1 more source

Role of IL‐25, IL‐33, and TSLP in triggering united airway diseases toward type 2 inflammation

Allergy. European Journal of Allergy and Clinical Immunology, 2020
Under the concept of "united airway diseases," the airway is a single organ wherein upper and lower airway diseases are commonly comorbid. The upper and lower airways are lined with respiratory epithelium that plays a vital role in immune surveillance ...
H. Hong, Shumin Liao, Fenghong Chen, Qintai Yang, D. Wang   +4 more
semanticscholar   +1 more source

Airway Remodeling in Asthma: Tumor of the Airway? [PDF]

Respiration, 2013
properties and the therapy has been shown to have an acute and sustained beneficial effect on lung function (changes in FEV 1 ) in chronic persistent asthma [6] . Antileukotrienes do not have major side effects and appear to be well tolerated by most patients [7] , but a limitation of their widespread use may be due to the large percentage of ...
Chun Y, Seow, Stephan, van Eeden
openaire   +2 more sources

Inflammatory cytokines can be monitored in exhaled breath particles following segmental and inhalation endotoxin challenge in healthy volunteers

Scientific Reports, 2022
Particles in exhaled air (PEx) are generated when collapsed small airways reopen during breathing. PEx can be noninvasively collected by particle impaction, allowing the analysis of undiluted epithelial lining fluid (ELF).
Olaf Holz, Meike Müller, Saskia Carstensen, Anna-Carin Olin, Jens M. Hohlfeld   +4 more
doaj   +1 more source

Difficult Airway Society 2015 guidelines for management of unanticipated difficult intubation in adults

British Journal of Anaesthesia, 2015
These guidelines provide a strategy to manage unanticipated difficulty with tracheal intubation. They are founded on published evidence. Where evidence is lacking, they have been directed by feedback from members of the Difficult Airway Society and based
C. Frerk, V. Mitchell, A. McNarry, C. Mendonca, R. Bhagrath, Anil K Patel, E. O'sullivan, N. Woodall, I. Ahmad   +8 more
semanticscholar   +1 more source

More Than Just a Barrier: The Immune Functions of the Airway Epithelium in Asthma Pathogenesis

Frontiers in Immunology, 2020
Allergic bronchial asthma is a chronic disease of the airways that is characterized by symptoms like respiratory distress, chest tightness, wheezing, productive cough, and acute episodes of broncho-obstruction. This symptom-complex arises on the basis of
A. Frey, L. Lunding, J. C. Ehlers, M. Weckmann, U. Zissler, M. Wegmann   +5 more
semanticscholar   +1 more source

Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells

bioRxiv, 2020
The derivation of self-renewing tissue-specific stem cells from human induced pluripotent stem cells (iPSCs) would shorten the time needed to engineer mature cell types in vitro and would have broad reaching implications for the field of regenerative ...
F. Hawkins, Shingo Suzuki, M. Beermann, Cristina Barillà, Ruobing Wang, C. Villacorta-Martin, A. Berical, J. Jean, Jake Le Suer, T. Matte, C. Simone-Roach, Yang Tang, Thorsten M. Schlaeger, Thorsten M. Schlaeger, A. Crane, Nadine Matthias, Sarah X. Huang, S. Randell, Joshua H. Wu, Jason R. Spence, Gianni Carraro, B. Stripp, A. Rab, Eric J. Sorsher, A. Horani, S. Brody, B. Davis, D. N. Kotton   +27 more
semanticscholar   +1 more source