Results 71 to 80 of about 2,432,490 (285)

The effect on respiratory mechanics when using a Jackson surgical table in the prone position during spinal surgery [PDF]

Korean Journal of Anesthesiology, 2010
BackgroundRespiratory dynamics may be monitored and evaluated indirectly by measuring the peak inspiratory pressure and plateau pressure. In this study, the respiratory dynamics of patients undergoing spinal surgery using a Jackson surgical table were ...
Yoontae Nam, Ann Misun Yoon, Yoon Hee Kim, Seok Hwa Yoon   +3 more
doaj   +1 more source

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Advanced Science, EarlyView.
The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin, Lars P. Lunding, Dominic Ferber, Hannes Buthmann, Ilka Schreier, Carlotta Bosio, Ann‐Kathrin Dobbelstein, Anna Klawonn, Rebecca C. Coll, Lena Bauernhofer, Sandro Keller, Matthias Geyer, Michael Wegmann, Andra B. Schromm, Günther Weindl   +16 more
wiley   +1 more source

A Comprehensive Microbial Gene Catalog of the Human Airway Microbiome Across Anatomical Sites and Geographic Regions

Advanced Science, EarlyView.
An integrated Human Airway Microbiome Gene Catalog (iHAMGC) is constructed from 12,273 metagenomic airway samples, providing a high‐resolution reference of respiratory microbial genes. The catalog enables systematic exploration of taxonomic and functional variation across airway niches and geographic regions, revealing site‐specific and region ...
Qing Zhang, Dashu Li, Bo Liu, Yue Zhang, Min Li, Ruochun Guo, Yawen Ni, Shibin Chen, Biao Ni, Lijie Qiu, Guorui Xing, He Dong, Qiulong Yan, Shenghui Li, Xiaohui Zou, Bin Cao   +15 more
wiley   +1 more source

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

Simple snoring: Not quite so simple after all? [PDF]

, 2014
Simple snoring (SS), in the absence of obstructive sleep apnoea (OSA), is a common problem, yet our understanding of its causes and consequences is incomplete.
Wilson, Janet, Ellis, Jason, Deary, Vincent, Barclay, Nicola, Coulter, Cheryl   +4 more
core   +1 more source

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

Postoperative nasal airway resistance is correlated with changes in anterior nasal cavity volume following posterior and superior movement caused by Le Fort I osteotomy

Advances in Oral and Maxillofacial Surgery
Purpose: This study aimed to analyse the relationship between changes in the anterior nasal cavity volume and nasal airway resistance following posterosuperior movement of the maxilla. Materials and methods: We studied 16 patients (13 female, 3 male) who
Jing Yuan, Kazuya Haraguchi, Taishi Ohtani, Kikuo Sakamoto, Manabu Habu, Izumi Yoshioka   +5 more
doaj   +1 more source

THE EFFECT OF PROPRANOLOL ON AIRWAY RESISTANCE

British Journal of Anaesthesia, 1967
The effect of propranolol on the airway resistance (AWR) of eighteen normal and seven asthmatic subjects has been studied by whole body plethysmography. In normal subjects there was a significant mean rise in AWR which was never accompanied by any respiratory upset.
A G, Macdonald, C G, Ingram, R S, McNeill   +2 more
openaire   +2 more sources

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Spirometric Variations in Adults with Controlled Hypertension: A Cross-sectional Study from Eastern India [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Hypertension’s impact on global health is vast, yet its link to Indian pulmonary function remains unclear. Despite maintaining controlled blood pressure, hypertensive individuals may harbour undetected pulmonary deficits, necessitating a ...
Sujoy Mukherjee, Debalina Sengupta, Parthasarathy Sinha , Sanhita Mukherjee, Yogesh Kumar   +4 more
doaj   +1 more source