Results 71 to 80 of about 1,675,974 (298)

Mechanisms altering airway smooth muscle cell Ca(2+) homeostasis in two asthma models [PDF]

, 2008
Background: Asthma is characterized by airway remodeling, altered mucus production and airway smooth muscle cell (ASMC) contraction causing extensive airway narrowing. In particular, alterations of ASMC contractility seem to be of crucial importance. The
Kellner, Julia, Tantzscher, Juliane, Edelmann, Martin, Bergner, Albrecht, Oelmez, Hamza, Huber, Rudolf M., Fischer, Rainald   +6 more
core   +1 more source

Awake or asleep approach to difficult airway during microlaryngeal surgery [PDF]

, 2020
Introduction: Patients presenting for microlaryngeal surgery frequently have a difficult airway. The chosen approach to this airway depends on the pathology and the patient’s symptoms.
Nizamova, N.; Department of ENT Surgery; University Hospital “Queen Giovanna”- ISUL; Medical University - Sofia, Popov, T.; Department of ENT Surgery; University Hospital “Queen Giovanna”- ISUL; Medical University - Sofia, Popova, D.; Department of ENT Surgery; University Hospital “Queen Giovanna”- ISUL; Medical University - Sofia, Rangachev, J.; Department of ENT Surgery; University Hospital “Queen Giovanna”- ISUL; Medical University - Sofia, Marinov, Ts.; Department of Anesthesiology and Intensive Care; University Hospital “Queen Giovanna”- ISUL; Medical University - Sofia, Belitova, M.; Department of Anesthesiology and Intensive Care; University Hospital “Queen Giovanna”- ISUL; Medical University - Sofia   +5 more
core   +1 more source

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

A Case Report Describing Three Cases of Challenging or Failed Intubation after Cervical Spine Surgery: A Peril of Early Extubation

The Surgery Journal, 2019
Postoperative airway complications can be a common, yet perhaps underappreciated, complication in patients undergoing cervical spine surgery. Presented here are three cases in which patients experienced postoperative airway compromise, resulting in ...
Puneet Mishra, Kelly Louise Mishra, Cassandra Palmer, Amy Robertson   +3 more
doaj   +1 more source

Pediatric airway management in undiagnosed congenital subglottic stenosis patients

The Indian Anaesthetists' Forum, 2020
Pediatric unanticipated difficult airway in cases of subglottic stenosis (SGS) is always a challenge. We present two cases of SGS which were managed according to the pediatric difficult intubation protocols where supraglottic device was used as secondary
Deepak Dwivedi, Gunjan Dwivedi, Vikas Gupta, Shreyas Kate   +3 more
doaj   +1 more source

Metformin reduces airway glucose permeability and hyperglycaemia-induced Staphylococcus aureus load independently of effects on blood glucose [PDF]

, 2013
Background Diabetes is a risk factor for respiratory infection, and hyperglycaemia is associated with increased glucose in airway surface liquid and risk of Staphylococcus aureus infection.
Garnett, James P, Tregoning, John S, Baines, DL, Baines, Deborah L, Knight, Gwenan M, Naik, S, Lindsay, JA, Tregoning, JS, Naik, Sonam, Garnett, JP, Baker, EH, Lindsay, Jodi A, Gill, S, Baker, Emma H, Gill, Simren, Knight, GM   +15 more
core   +1 more source

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

Research advances on epigenetic modifications in dendritic cells in allergic rhinitis

Frontiers in Immunology
Allergic rhinitis (AR), a globally prevalent allergic airway disorder, fundamentally involves CD4+T cell subset imbalance, notably T helper 2 (Th2) hyperpolarization.
Siyu Duan, Siyu Duan, Siyu Duan, Siyu Duan, Siyu Duan, Ziyi Jia, Ziyi Jia, Ziyi Jia, Ziyi Jia, Ziyi Jia, Leilei Zheng, Leilei Zheng, Leilei Zheng, Leilei Zheng, Leilei Zheng, Yisha Wu, Yisha Wu, Yisha Wu, Yisha Wu, Yisha Wu, Zhihan Xu, Zhihan Xu, Zhihan Xu, Zhihan Xu, Zhihan Xu, Haiyi Peng, Haiyi Peng, Haiyi Peng, Haiyi Peng, Haiyi Peng, Jinmei Xue, Jinmei Xue, Jinmei Xue, Jinmei Xue, Jinmei Xue   +34 more
doaj   +1 more source

Postoperative changes in the pharyngeal airway space through computed tomography evaluation after mandibular setback surgery in skeletal class III patients: 1-year follow-up

Maxillofacial Plastic and Reconstructive Surgery, 2021
Background This study evaluated the pharyngeal airway space changes up to 1 year after bilateral sagittal split osteotomy mandibular setback surgery and bimaxillary surgery with maxillary posterior impaction through three-dimensional computed tomography ...
No Eul Kang, Dae Hun Lee, Ja In Seo, Jeong Keun Lee, Seung Il Song   +4 more
doaj   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source