Results 31 to 40 of about 14,328 (189)
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Rare but severe adverse events (AEs) associated with mRNA‐lipid nanoparticle (LNP) COVID‐19 vaccines, such as Comirnaty, include anaphylaxis and inflammatory organ disorders, but their underlying mechanisms are poorly understood. We aimed to develop an animal model to study these phenomena.
László Dézsi +13 more
wiley +1 more source
Granice, relacje i napięcia. Wyzwania badań biograficznych w obrębie instytucji akademickich
Łódzkie Studia EtnograficzneW artykule omówiono wyzwania związane z badaniami biograficznymi prowadzonymi w kontekście instytucji akademickich. Badania te są szczególnie wartościowe dla zrozumienia relacji władzy, dynamiki instytucjonalnej oraz sposobów, w jakie biografie jednostek
Julia Michcik
doaj +1 more source
Beszámoló a Berend T. Iván 90. születésnapja tiszteletére tartott online konferenciáról
Köz-gazdaság, 2021 2020 decemberében 90. születésnapját ünnepelte Berend T. Iván, korunk egyik legnevesebb magyar társadalomtudósa, a Budapesti Corvinus Egyetem jogelődjének korábbi rektora.
Köz- gazdaság
doaj
Socialvetenskaplig tidskrift, 2016 Relationen mellan praktisk kunskap och akademisk kompetens undersöks i en kvalitativ studie. Hur kan klyftan mellan forskning och praktik överbryggas? Hur värderar sakkunniga praktiska meriter i jämförelse med övriga meriter vid tillsättning av akademiska tjänster?
openaire +2 more sources
Dualsteric and dual‐acting modulation of muscarinic receptors by antagonist KH‐5
British Journal of Pharmacology, EarlyView.Abstract Background and purpose Muscarinic acetylcholine receptors are key therapeutic targets, and ligands engaging both orthosteric and allosteric sites may offer improved selectivity and efficacy. Here, we investigated whether the muscarinic antagonist KH‐5 acts as a dualsteric antagonist and defined its mode of interaction with muscarinic receptors.
Alena Janoušková‐Randáková +3 more
wiley +1 more source
The sorting nexin Snx21 promotes flotillin‐mediated endocytosis
The FEBS Journal, EarlyView.In this study, we describe a novel function of the previously uncharacterized Snx21 protein as a specific positive regulator of flotillin‐mediated endocytic trafficking. Snx21 is recruited to endosomal membranes via binding to PI(3)P, and it colocalizes with flotillins on the surface of late endosomes.
Tamás Maruzs +9 more
wiley +1 more source
Tankyrase‐2 regulates adipocyte differentiation through AMPK/mTOR signaling
The FEBS Journal, EarlyView.Tankyrase 2 (TNKS2), a PARP family member, underpins adipocyte differentiation. TNKS2 controls LKB1 protein level, and consequently, the activity of the mTOR/AMPK system and adipocyte differentiation through a layered process. Pharmacological inhibition of TNKS2 leaves other PARPs and DNA repair active and therefore represents a novel target in ...
Boglarka Rauch +7 more
wiley +1 more source
Insect Conservation and Diversity, EarlyView.Grassland fragmentation effects on cavity‐nesting Hymenoptera are habitat‐specific. Isolated sand steppe fragments are associated with higher brood‐cell abundance. In loess steppes, higher flower frequency increases bee brood‐cell production and parasitoid activity. Abstract The global decline in insects threatens ecosystem functioning, but the drivers
Edina Török +6 more
wiley +1 more source