Evaluation of the theoretical risk of cross-reactivity among recently identified food allergens for dogs. [PDF]
Background: There is increasing evidence of cross‐reactivity between allergens of close or distant species. The A‐RISC (Allergens'–Relative Identity, Similarity and Cross‐reactivity) index helps evaluate the risk of theoretical cross‐reactivity between proteins of the same family among different species.
Olivry T, O'Malley A, Chruszcz M.
europepmc +2 more sources
Efficacy of subcutaneous allergen immunotherapy in atopic dogs: A retrospective study of 664 cases. [PDF]
Background –Canine atopic dermatitis (cAD) is an allergic skin disease affecting approximately 10% of dogs. Allergen immunotherapy (AIT) is currently the only treatment option able to induce tolerance to the causative allergens. Objective – To retrospectively establish the efficacy of AIT in atopic dogs.
Fennis EEM +6 more
europepmc +2 more sources
An international seroprevalence survey of the IgE sensitisation to the Dermatophagoides farinae house dust mite and two of its major allergens (Der f 2, Zen 1) in atopic dogs. [PDF]
Background – Dogs with atopic dermatitis are often immunoglobulin (Ig)E‐sensitised to Dermatophagoides farinae (Df) house dust mites, yet limited data exist on the sensitisation rates to the individual Df allergens, Der f 2 and Zen 1. Objectives – To determine the IgE sensitisation rates to Df, Der f 2 and Zen 1 in atopic dogs from geographically ...
Favrot C, Olivry T, Iwasaki T.
europepmc +2 more sources
A prospective study evaluating the correlation between local weather conditions, pollen counts and pruritus of dogs with atopic dermatitis. [PDF]
Abstract Background Canine atopic dermatitis (cAD) is a hereditary, generally pruritic and predominantly T‐cell‐driven inflammatory skin disease, involving an interplay between skin barrier abnormalities, allergen sensitisation and microbial dysbiosis.
Widorn L, Zabolotski Y, Mueller RS.
europepmc +2 more sources
Immunotherapy using pullulan-conjugated Der f 2 allergen in canine atopic dermatitis: An anti-inflammatory agent-sparing approach. [PDF]
Background – Allergen immunotherapy is used as aetiological treatment for canine atopic dermatitis (cAD). Objective – To assess the anti‐inflammatory agent‐sparing effect over 1 year of immunotherapy using pullulan‐conjugated recombinant Der f 2 (rDf2‐P). Conclusions and Clinical Relevance – Der f 2‐P immunotherapy can lead to a rapid reduction in anti‐
Nagata M +7 more
europepmc +2 more sources
Background – Hymenoptera envenomation with honey bee (Apis mellifera) and paper wasp (Polistes spp.) may cause life‐threatening anaphylaxis in dogs. In human patients, clinical history, intradermal testing (IDT) and measurement of allergen‐specific serological immunoglobulin (Ig)E (sIgE) are used to support a diagnosis of Hymenoptera venom ...
Hilary H. Chan +3 more
wiley +1 more source
Background – Grass leaf has been suspected to cause immunoglobulin (Ig)E‐mediated immediate hypersensitivity reactions both in humans and in dogs. However, most studies in this area are case control studies without in vitro data showing the involvement of IgE in the reaction.
Ken Mason, Janet Davies, Merja Ruutu
wiley +1 more source
The safety of rush immunotherapy in the management of canine atopic dermatitis—230 cases
Background – The duration of the induction phase of allergen‐specific immunotherapy conventionally is a period of several weeks, during which the volume of an allergen solution, administered by injection, is gradually increased until the maintenance dose is reached.
Tamara Weitzer, Ralf Mueller
wiley +1 more source
Background – Glycerinated allergen extracts contain 50% glycerin, an excellent preservative. While glycerin is a recognised irritant in humans, the utility of glycerinated extracts for intradermal testing has not been validated in dogs. Hypothesis/Objective – To determine and compare the effects of glycerin on immediate cutaneous reactions to ...
Frane Banovic, Cheryl Vargo, Tara Denley
wiley +1 more source
Background – The caninised monoclonal antibody lokivetmab (LKV), directed at interleukin (IL)‐31, is very effective at controlling pruritus in most dogs with atopic dermatitis (AD). However, evidence exists that IL‐31 is not required for the induction of acute allergic skin inflammation, which might explain why this treatment is less efficacious in ...
Chie Tamamoto‐Mochizuki +4 more
wiley +1 more source

