Results 161 to 170 of about 814,837 (335)

Structural and biochemical analyses of alanine racemase from the multidrug-resistantClostridium difficilestrain 630 [PDF]

, 2014
Oluwatoyin A. Asojo, Sarah K. Nelson, Sara Mootien, Yashang Lee, Wanderson Rezende, Daniel Hyman, Monica M. Matsumoto, Scott Reiling, Alan Kelleher, Michel Ledizet, Raymond A. Koski, Karen Anthony   +11 more
openalex   +1 more source

NNMT Orchestrates Metabolic‐Epigenetic Reprogramming to Drive Macrophage‐Myofibroblast Transition in Hypertrophic Scarring

Advanced Science, EarlyView.
In macrophage‐myofibroblast transition, upregulated NNMT depletes S‐Adenosylmethionine‌ (SAM) and nicotinamide adenine dinucleotide(NAD+), thereby triggering epigenetic reprogramming via Histone H3 Lysine 27 acetylation (H3K27ac) accumulation at the promoter region of master transcription factor Prrx1.
Xiwen Dong, Weinan Guo, Yuxuan Qian, Wenyan Jin, Xiaozhen Li, Jingyuan Yang, Qingrong Ni, Shuang Wu, Fanni Li, Hua Wang, Chunying Li, Hong Cai   +11 more
wiley   +1 more source

Substantially Altered Local and Systemic Immunity in Ischemia‐Free Versus Conventional Liver Transplantation

Advanced Science, EarlyView.
This study investigates how ischemia‐free liver transplantation (IFLT) shapes both local and systemic immune responses compared with conventional liver transplantation (CLT). Our findings demonstrate that IFLT confers significant immunological protection by attenuating the STAT3‐HIF‐1α axis and enhancing the Heme‐HMOX1 pathway, two regulatory networks ...
Tao Luo, Shuai He, Shirui Chen, Dongmei Ye, Shibo Zhang, Di Liu, Dawei Zou, Linhe Wang, Huadi Chen, Jinghong Xu, Huanjie Liu, Ruiting Liu, Xi Tan, Yitong Wang, Jiayi Zeng, Runbing Mo, Yuexin Li, Yuyi Zhang, Tanyiyang Ruan, Tielong Wang, Zehua Jia, Yu Jia, Tongdi Fang, Yimou Lin, Xiaorui Liu, Yunhua Tang, Maogen Chen, Qiang Zhao, Anbin Hu, Weiqiang Ju, Yi Ma, Dongping Wang, Xiaofeng Zhu, Schlegel Andrea, Yuan Zhai, Kwan Man, Tullius G. Stefan, Yifang Gao, Jinxin Bei, Xiaoshun He, Zhiyong Guo   +40 more
wiley   +1 more source

Genetic Mapping of a Mutant Defective in d, l -Alanine Racemase in Bacillus subtilis 168 [PDF]

, 1973
Michael Dul, Frank E. Young
openalex   +1 more source

Biocatalytic Nanoregulators Restore Joint Redox‐Immune Homeostasis in Rheumatoid Arthritis

Advanced Science, EarlyView.
Mesenchymal stem cell‐derived extracellular vesicles (EVs) coat ruthenium‐loaded metal‐organic frameworks (Ru@ZrMOF), creating a targeted therapeutic (Ru@ZrMOF/EVs). This platform scavenges ROS, generates oxygen, and polarizes macrophages from M1 to M2, alleviating inflammation, inhibiting pannus, promoting cartilage repair, and downregulating HIF‐1α ...
Xingheng Wang, Jianbo Huang, Shuwei Zhang, Sujiao Cao, Fangxue Du, Liqiang Zhou, Li Qiu, Yuanjiao Tang   +7 more
wiley   +1 more source

β-Alanine Is an Unexploited Neurotransmitter in the Pathogenesis and Treatment of Alzheimer's Disease. [PDF]

NeuroSci
Wozniczka CM, Weaver DF.
europepmc   +1 more source

Sleep-Awake Profile Related Circadian D-Alanine Rhythm in Human Serum and Urine

, 2017
Akiko Morikawa, Hideoki Fukuoka, Keiko Uezono, Masashi Mita, Satoru Koyanagi, Shigehiro Ohdo, Kiyoshi Zaitsu, Kenji Hamase   +7 more
openalex   +2 more sources

High-Normal Alanine Aminotransferase as a Predictor of Significant Liver Histological Injury in Chronic Hepatitis B Virus Infection with Different HBV DNA Levels

, 2022
Shan Ren, Junfeng Lu, Kefei Wang, Lina Ma, Yanhong Zheng, Zheng Sujun, Xinyue Chen   +6 more
openalex   +1 more source

Identification of PKN2 and MOB4 as Coordinators of Collective Cell Migration

Advanced Science, EarlyView.
Through a genetic screen, PKN2 and MOB4 are identified as two proteins regulating the healing of an epithelial model wound. PKN2 promotes collective cell migration by maintaining the cohesion of cell monolayers from their lateral junctions, whereas MOB4 restrains collective cell migration and provides a lamellipodial cue for front‐rear polarity in ...
Artem I. Fokin, Yueying Lin, Dmitry Y. Guschin, Hsiang‐Ying Chen, John James, Jie Yan, Pascal Silberzan, Alexis M. Gautreau   +7 more
wiley   +1 more source

A Hybrid Photo/Biocatalytic System for the Sustainable Synthesis of L-Alanine From Urea and Pyruvate. [PDF]

ChemSusChem
Yamada K, Amao Y.
europepmc   +1 more source