Results 261 to 270 of about 897,077 (404)

Studies on the Synthesis of Protein Analogues. XVII. L. Tyrosine Copolymers Containing Glycine, L-Phenylalanine, and Glycine and DL-Alanine

, 1959
野口 順蔵, 斎藤 智夫
openalex   +2 more sources

Enhancing the Protein Stability of an Anticancer VHH‐Fc Heavy Chain Antibody through Computational Modeling and Variant Design

Advanced Science, EarlyView.
In this study, a computational pipeline is developed to systematically evaluate the conformational stability, disulfide bond reduction state, and aggregation and degradation tendencies of an anticancer VHH‐Fc fusion antibody. Based on the mechanistic insights, antibody variants with enhanced stability and increased yield are successfully designed. This
Yuan Fang, Menghua Song, Tianning Pu, Xiaoqing Song, Kailu Xu, Pengcheng Shen, Ting Cao, Yiman Zhao, Simon Hsu, Dongmei Han, Qiang Huang   +10 more
wiley   +1 more source

SHINE: Deterministic Many-to-Many Clustering of Molecular Pathways. [PDF]

J Chem Inf Model
Chen L, Leung JMG, Zsigmond K, Chong LT, Miranda-Quintana RA.   +4 more
europepmc   +1 more source

Studies on Optically Active Amino Acids. II. Partially Asymmetric Synthesis of 3-(3, 4-Methylenedioxyphenyl) alanine

, 1962
Shun‐ichi Yamada, Takayuki Shioiri, Tozo Fujii   +2 more
openalex   +2 more sources

Communications Among Neurocytes in Parkinson's Disease Regulated by Differential Metabolism and Blood‐Brain Barrier Traversing of Chiral Gold Cluster‐MOF Integrated Nanoparticles

Advanced Science, EarlyView.
This study have loaded chiral gold nanoclusters onto the inner and outer surfaces of ZIF and uncovers the biodistribution, metabolic variances, and therapeutic mechanism of chiral nanoparticles, providing deep insights into the nanobiological effects of chiral anti‐inflammatory nanomedicines in PD therapy for future clinical transformation.
Junyang Chen, Gaoxiang Xu, Runpu Shen, Jianzhong Xu, Congcong Lu, Xin Li, Qi Feng, Qing Li   +7 more
wiley   +1 more source

PRMT5 Inhibitor Synergizes with Chemotherapy to Induce Resembling Mismatch Repair Deficiency and Enhance Anti‐TIGIT Therapy in Microsatellite‐Stable Colorectal Cancer

Advanced Science, EarlyView.
Microsatellite‐stable (MSS) colorectal cancer (CRC) resists immunotherapy. PRMT5 inhibition enhances CPT‐11 sensitivity, inducing a PMS2‐deficient‐like state and cytosolic dsDNA release, which activates the cGAS‐STING pathway to promote anti‐tumor immunity. However, this combination therapy upregulates TIGIT expression on CD8+ T cells, and the addition
Jiang Zhu, Shenao Fu, Xi Zou, Hanjiang Zeng, Guangzu Cui, Yinghui Peng, Diya Tang, Fan Zhang, Hong Shen, Shan Zeng, Ying Han   +10 more
wiley   +1 more source

Serum activity of alanine aminotransferase (ALT) as an indicator of health and disease

Hepatology, 2008
W. Kim, S. Flamm, A. D. Di Bisceglie, H. Bodenheimer   +3 more
semanticscholar   +1 more source

Promoter engineering for enhanced 3-hydroxypropionic acid production in <i>Pichia pastoris</i>. [PDF]

Synth Syst Biotechnol
Chen S, Zhang M, Wu X, Bai F, Gao L, Shen Y, Dou S, Cai P, Zhou YJ.   +8 more
europepmc   +1 more source

β-Alanin [PDF]

, 2017
openaire   +2 more sources

Dipyridamole Acts as Clinical Ferroptosis Inhibitor to Prevent from Tissue Injury

Advanced Science, EarlyView.
Dipyridamole acts as a clinically used compound to suppress ferroptosis. Dipyridamole down‐regulates the expression of RNF126, which is an E3 ligase to ubiquitinate SLC7A11 for proteasome degradation. The deficiency of SLC7A11 largely abolishes the protective role of dipyridamole both in vitro and in vivo.
Xiao Zhuang, Shuang Shi, Shuo Liu, Yaqiong Jiao, Bin Huang, Yinghong Yang, Li Yang, Xinquan Yang, Hui Wang, Chunhui Liang, Dandan Song, Huaxiang Yu, Dan Zou, Qi Sun, Shu Yang, Chengqian Yin, Jian Li, Yiming Liu, Junxia Min, Fudi Wang, Yong Nian, Lutao Du, Bo Chu   +22 more
wiley   +1 more source