Results 201 to 210 of about 300,064 (307)

Cytosolic Phosphoenoylpyruvate Carboxykinase Deficiency: Clinical, Biochemical, and Genetic Features of Five Non‐Finnish Patients

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Cytosolic phosphoenoylpyruvate carboxykinase (PEPCK‐C) is an essential, rate‐limiting enzyme in the gluconeogenesis pathway. PEPCK‐C deficiency presents with hypoglycaemia, hyperlactataemia and hepatopathy, and was first reported in association with bi‐allelic PCK1 variants in 2014.
Isaac Bernhardt, Polona Le Quesne Stabej, Claire Hart, Mark De Hora, Sarah Hulley, Mark Anderson, Harry G. Leitch, Hugh Lemonde, Bryony Ryder, James Davison   +9 more
wiley   +1 more source

Determining Upper Limit of Alanine Aminotransferase in Iranian Cohort Population Using Ultrasound Screening for Liver Diseases. [PDF]

Middle East J Dig Dis
Ahmadi B, Naleini F, Moradinazar M, Anvari B.   +3 more
europepmc   +1 more source

Mapping quantitative trait loci underlying body weight changes that act at different times during high‐fat diet challenge in collaborative cross mice

Animal Models and Experimental Medicine, EarlyView.
Over one billion people worldwide suffer from obesity, and the number is continually rising. Animal models, especially mouse models, are crucial to identifying the genetic components of complex disorders and exploring the potential applications of these genetic findings.
Hanifa J. Abu‐Toamih Atamni, Iqbal M. Lone, Ilona Binenbaum, Kareem Midlej, Eleftherios Pilalis, Richard Mott, Aristotelis Chatziioannou, Fuad A. Iraqi   +7 more
wiley   +1 more source

Relationship between Kawasaki disease and alanine aminotransferase levels in pediatric patients. [PDF]

World J Hepatol
Pan Y, Jiao FY.
europepmc   +1 more source

Metabolic and biochemical profiling reveals phenotypic heterogeneity in Zucker diabetic fatty rats

Animal Models and Experimental Medicine, EarlyView.
Genetically uniform Zucker Diabetic Fatty (ZDF) rats spontaneously develop four distinct metabolic phenotypes despite identical housing and diet conditions. Each phenotype exhibits unique biomarker signatures encompassing glucose homeostasis, insulin secretion, polyol pathway activation, oxidative stress, inflammatory cytokines, and neurotrophic ...
Marek Lepáček, Pavol Boďo, Barbora Kaločayová, Marta Šoltésová Prnová   +3 more
wiley   +1 more source

Impact of baseline alanine aminotransferase levels on the efficacy of dapagliflozin and sitagliptin: Latent class analysis from the DIVERSITY-CVR study. [PDF]

Diabetes Obes Metab
Mochizuki K, Fuchigami A, Hirose T, Uchino H.   +3 more
europepmc   +1 more source

Methylophiopogonanone a attenuates pulmonary fibrosis by inhibiting SPP1‐mediated macrophage polarization via the PI3K/Akt pathway

Animal Models and Experimental Medicine, EarlyView.
Transcriptome sequencing identified secreted phosphoprotein 1 (SPP1) as a crucial target through which methylophiopogonanone A (MOA) ameliorates pulmonary fibrosis. Molecular docking and microscale thermophoresis (MST) assays confirmed a favorable binding affinity between MOA and SPP1.
Fan Yang, Tian Li, Weiran Jia, Dingjie Xu, Liangdan Sun, Yanlei Ge, Yiwei Shi, Hong Xu, Xudong Song, Fuyu Jin, Na Mao   +10 more
wiley   +1 more source

Association between the aspartate aminotransferase-to-alanine aminotransferase ratio and the reversion to normoglycemia in people with impaired fasting glucose: a 5-year retrospective cohort study. [PDF]

Front Endocrinol (Lausanne)
Zhang K, Chen L, Deng Z, Rong R, Xu L, Xu L, Zeng S, Hu H.   +7 more
europepmc   +1 more source

Metabolic Syndrome and Insulin Resistance Are Associated With Normal-Range Aspartate Aminotransferase, Alanine Aminotransferase, and Their Ratio in Chinese Women With Polycystic Ovary Syndrome. [PDF]

Clin Endocrinol (Oxf)
Feng J, Luo R, Cong J, Xia Q, Liu Y, Ge H, He H, Yang W, Wu X.   +8 more
europepmc   +1 more source

Adverse Prognostic Impact of Pretransplant Serum Ferritin and Hepcidin on Survival Outcomes After Allogeneic Hematopoietic Stem Cell Transplantation

American Journal of Hematology, EarlyView.
Michelle Pirotte, Marianne Fillet, Laurence Seidel, Evelyne Willems, Sophie Servais, Fréderic Baron, Yves Beguin   +6 more
wiley   +1 more source