Results 241 to 250 of about 457,916 (395)

Multifunctional Framework Nucleic Acid Vehicle for Antibiotic Sensitization and Treatment of Methicillin‐Resistant Staphylococcus aureus

Aggregate, EarlyView.
A self‐assembling, aggregation‐enhanced tetrahedral DNA nanostructure (tFNA), termed TACs, enables localized accumulation and sustained release of ceftriaxone while co‐delivering antisense oligonucleotides that silence mecA, reduce PBP2a expression, and restore β‐lactam susceptibility in MRSA.
Yicheng Zhao, Jingyi Si, Shisong Jing, Bingmei Wang, Yueshan Xu, Jiyu Guan, Quan Liu, Jianlei Shen, Min Lv, Li Wang, Changfeng Zhu   +10 more
wiley   +1 more source

From Amino Acids to α‐Keto Acids via β‐Elimination and Transamination Initiates a Pathway to Prebiotic Reaction Networks

Angewandte Chemie, EarlyView.
A reaction starting from two amino acids, phosphoserine and Gly, reveals a pathway to the α‐keto acid building blocks pyruvate and glyoxylate, key components of a plausible early metabolic system. A one‐pot β‐elimination and transamination sequence also initiates a cascade of protometabolic transformations that provide crucial insights into the ...
Louis M.P. Ter‐Ovanessian, Kate L. Ryan, Joshua Shaarda, R. Trent Stubbs, Ramanarayanan Krishnamurthy, Greg Springsteen   +5 more
wiley   +2 more sources

Role of alanine aminotransferase in crop resilience to climate change: a critical review. [PDF]

Physiol Mol Biol Plants
Agrawal N, Chunletia RS, Badigannavar AM, Mondal S.   +3 more
europepmc   +1 more source

Hepatitis B virus viral dynamics: effects of drug dose and baseline alanine aminotransferase [PDF]

, 2002
Ruy M. Ribeiro, Alan S. Perelson
openalex   +1 more source

Immunostimulatory DNA Tetrahedron‐Based Nanovaccine Combined With Immune Checkpoint PD‐1 Blockade for Boosting Systemic Immune Responses Against Oral Squamous Cell Carcinoma

Aggregate, EarlyView.
This study introduces an immunomodulatory DNA tetrahedral framework nucleic acid‐based nanovaccine tFNA‐CpG. The functionalized nanovaccine shows stable and well‐defined morphological characteristics and can be efficiently taken up by APCs. When combined with the immune checkpoint inhibitor anti‐PD‐1, it notably ameliorated the immunosuppressive ...
Xueting Yang, Yun Wang, Yan Yang, Sicheng Zhang, Dianri Wang, Yi Luo, Chunyan Shui, Yongcong Cai, Ruoyi Yang, Shuang Dong, Mu Yang, Yunfeng Lin, Chao Li   +12 more
wiley   +1 more source

MOF Coating Enhances the Ion Tolerance of Micromotors

Angewandte Chemie, EarlyView.
This work reported a novel method to significantly enhance the ion tolerance of EMNMs using a MOF coating via controllable heteroepitaxial growth, enabling effective motion in high‐salt environments and propulsion through biological tissues under 980 nm NIR light, with potential applications in targeted drug delivery.
Leyan Ou, Kunfeng Liu, Yifan Zhang, Wanyuan Li, Zixian Liang, Dapeng Lei, Hao Sun, Mojun Chen, Jizhuang Wang, Jinyao Tang, Dan Li   +10 more
wiley   +2 more sources

Association between aspartate aminotransferase to alanine aminotransferase ratio and mortality in critically ill patients with end stage renal disease. [PDF]

Sci Rep
Liang X, Wang Q, Lai K, Li X, Gui S, Li Y, Xing Z.   +6 more
europepmc   +1 more source

Clinical guidelines for the management of cutaneous leishmaniasis in British military personnel. [PDF]

, 2005
Bailey, MS, Beeching, NJ, Bryceson, AD, Chiodini, PL, Ellis, CJ, Green, AD, Lockwood, DN, O'Dempsey, TJ   +7 more
core   +1 more source

Deep‐Learning Model for Central Nervous System Infection Diagnosis and Prognosis Using Label‐Free 3D Immune‐Cell Morphology in the Cerebrospinal Fluid

Advanced Intelligent Systems, EarlyView.
Early diagnosis and prognosis prediction of central nervous system infections are critical. This study introduces a deep‐learning model utilizing cerebrospinal fluid immune‐cell morphology captured via 3D holotomography. The model effectively predicts infection etiology and prognosis, achieving high accuracy.
Bo Kyu Choi, Ho Heon Yang, Jong Hyun Kim, JaeSeong Hong, Kyung Min Kim, Yu Rang Park   +5 more
wiley   +1 more source

A variant in HMMR/HMMR-AS1 is associated with serum alanine aminotransferase levels in the Ryukyu population. [PDF]

Sci Rep
Ohyama N, Matsunami M, Imamura M, Yoshida A, Javed A, Liu X, Kimura R, Matsuda K, BioBank Japan Project, Terao C, Maeda S.   +10 more
europepmc   +1 more source