Results 311 to 320 of about 457,916 (395)

Biosynthesis of Ephedrine is Initiated by Pyridoxal Phosphate‐Dependent Formation of Cathinone

ChemBioChem, Accepted Article.
Ephedra alkaloids possess some of the most basic structures of alkaloids. Despite their importance for human use and their commercial relevance, the biosynthesis of ephedra alkaloids has remained enigmatic. The predominant biosynthetic pathway in the literature proposes a thiamine‐dependent caboligation followed by a transaminase, although no candidate
Karina Witte, Anne Behrens, Hannes M. Schwelm, Volker Auwärter, Michael Müller   +4 more
wiley   +1 more source

Higher serum alanine aminotransferase levels and the incidence of hypertension: The Kailuan cohort study. [PDF]

Am J Prev Cardiol
Jia J, Yang Y, Liu F, Chen S, Deng Y, Guo T, Peng Z, Wang X, Ma X, Wu S.   +9 more
europepmc   +1 more source

Pharmacokinetics and Safety Evaluation of a New Generic Sitafloxacin: A Phase I Bioequivalence Study in Healthy Chinese Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Sitafloxacin is a new antibiotic drug belonging to the fourth generation quinolone antibiotics. The aim of this study was to evaluate the pharmacokinetics (PK), safety profiles, and bioequivalence of test and reference 50‐mg sitafloxacin tablets under fasting and fed conditions.
Yongfang Lei, Pan Luo, Yuzhu Chen, Liuliang Xue, Donglin Zhang, Xingxing Qi, Yinian Fang, Hengyi Yu, Zheng He, Qin Zuo, Chang Liu, Dong Liu, Xinhua Ren, Qian Chen   +13 more
wiley   +1 more source

Clinical Evidence of the Relationship Between Alanine Aminotransferase and Diabetic Kidney Disease. [PDF]

Diabetes Metab Syndr Obes
Bi Y, Yang Y, Yuan X, Wang J, Liu Z, Tian S, Sun C.   +6 more
europepmc   +1 more source

Pharmacokinetics, Safety, and Tolerability of Single‐Dose Dazukibart in Healthy Adults in China and Japan: Results From 2 Randomized, Double‐Blind, Phase 1 Studies

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Dazukibart is a humanized monoclonal antibody selectively targeting interferon‐β. The pharmacokinetics (PK), safety, tolerability, and immunogenicity of dazukibart were evaluated in 2 double‐blind, randomized, placebo‐controlled, single‐dose, Phase 1 studies in healthy adults in China (Study 1: N = 18; dazukibart 900 mg = 15; placebo = 3) and ...
Naihan Chen, Yamato Sano, Xiaohong Wang, Shuiyi Hu, Junichi Tabira, Xin Luo, Hiroki Yoshimatsu, John Prybylski, Myron Chu, Haiyan Li, Kenji Takazawa   +10 more
wiley   +1 more source

Triglyceride-glucose-alanine aminotransferase index: A noninvasive serum predictor for identifying the severity of pediatric nonalcoholic fatty liver disease. [PDF]

Medicine (Baltimore)
Noh ES, Hwang IT.
europepmc   +1 more source

Normal serum alanine aminotransferase activity in uncomplicated obesity

, 2005
Gianluca Iacobellis, Antonio Moschetta, Mária Cristina Ribaudo, Alessandra Zappaterreno, Concetta Valeria Iannucci, Frida Leonetti   +5 more
openalex   +1 more source

Safety, Tolerability, and Pharmacokinetics of Donanemab in Healthy Chinese Participants: A Phase 1, Randomized, Double‐Blind, Placebo‐Controlled Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Alzheimer's disease (AD), characterized by β‐amyloid (Aβ) plaques and neurofibrillary tangles, is the leading cause of dementia globally. Donanemab is a humanized immunoglobulin G1 in development as a treatment to slow AD progression. This study aimed to evaluate the safety, tolerability, pharmacokinetics (PKs), and immunogenicity of donanemab
Junyu Xu, Nan Zhao, Yihui Wang, Ivelina Gueorguieva, Chenxi Qian, Yimin Cui   +5 more
wiley   +1 more source

The incremental value of aspartate aminotransferase/alanine aminotransferase ratio combined with CURB-65 in predicting treatment outcomes in hospitalized adult community-acquired pneumonia patients with type 2 diabetes mellitus. [PDF]

BMC Pulm Med
Zhou H, Zhu X, Zhang Y, Xu W, Li S.
europepmc   +1 more source

Type 2 Diabetes in Children is Frequently Associated with Elevated Alanine Aminotransferase

, 2005
Kristen J. Nadeau, Georgeanna J. Klingensmith, Philip Zeitler   +2 more
openalex   +1 more source