Results 91 to 100 of about 276,470 (294)

Vascularized Liver‐on‐a‐Microsphere Reveals Alanine‐Glucose Metabolism‐Driven Regulation of Liver Function and Injury

Advanced Science, EarlyView.
A vascularized liver‐on‐a‐microsphere system is developed to recreate lobule‐like cellular organization and endothelial barrier function within compartmentalized hydrogel particles. The platform enhances hepatic performance and reveals alanine‐glucose cycle activation linked to improved detoxification capacity, offering a high‐throughput microscale ...
Jingyang Li, Zengnan Wu, Yingrui Zhang, Shulang Chen, Yongning Lin, Shiyu Chen, Tong Xu, Xianli Meng, Yi Zhang, Jin‐Ming Lin   +9 more
wiley   +1 more source

The Effects of Subacute Exposure of Peracetic Acid on Lipid Peroxidation and Hepatic Enzymes in Wistar Rats

Oman Medical Journal, 2010
Objectives: This study was undertaken to determine the effect of subacute exposure of peracetic acid on lipid peroxidation and hepatic enzymes in Wistar rats.Methods: 48 male animals in Treatment Group I, II and III received 0.2%, 2% and 20% peracetic ...
Abdoljalal Marjani
doaj  

A Machine Vision‐Guided Microphysiological Platform With Automated Microfluidics Enables Longitudinal Biomarker Monitoring and Emulation of Translationally Relevant Exposure Scenarios

Advanced Science, EarlyView.
A pneumatically actuated multi‐tissue microphysiological system is integrated with AI‐based machine vision and automatic sampling and replenishment systems. The platform allows for the emulation of translationally relevant long‐term pharmacokinetic exposure scenarios for multiple weeks while enabling longitudinal monitoring of response biomarkers ...
Jibbe Keulen, Yi Zhong, Laura Dangel, Sonia Youhanna, Reza Zandi Shafagh, Jinhye Ryu, Domnica‐Gabriela Gurau, Mathias Haag, Thomas E. Mürdter, Yingxin Liang, Iro Beligiani, Nicole Ziegler, Sabine Willems, Nayere Taebnia, Wouter van der Wijngaart, Volker M. Lauschke   +15 more
wiley   +1 more source

HUBUNGAN KADAR ANTIBODI HCV DENGAN ASPARTATE TRANSAMINASE DAN ALANINE TRANSAMINASE PADA PASIEN HEPATITIS C: RELATIONSHIP OF HCV ANTIBODY LEVELS WITH ASPARTATE TRANSAMINASE AND ALANINE TRANSAMINASE IN HEPATITIS C PATIENTS [PDF]

Penyakit hepatitis C adalah penyakit peradangan hati yang disebabkan oleh infeksi virus hepatitis C. Penelitian ini bertujuan untuk mengetahui hubungan antara kadar antibodi HCV dengan kadar Aspartate Transaminase (AST) dan Alanine Transaminase (ALT ...
I Made Sumarya, Ni Nyoman Suardani, I Nyoman Arsana   +2 more
core   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

Unraveling Bone‐Skin Crosstalk Enables miRNA Nanoformulation for Cutaneous Neurovascular Reconstruction in Diabetic Mice

Advanced Science, EarlyView.
This study unravels that bone fracture accelerates diabetic wound healing by releasing exosomal microRNA (miR‐130b‐3p). To mimic this bone‐skin crosstalk, we engineered a self‐assembling agomir‐130b‐3p nanocomplex. Delivered via a photocrosslinkable hydrogel, this bio‐inspired therapy provides sustained localized agomir release.
Tao Shen, Hongdou Shen, Weiyue Wu, Zhuoying Jiang, Bin Liu, Yansi Xian, Rui Peng, An Yan, Yu Ben, Yong Shi, Xiang Chen, Baosheng Guo, Qing Jiang, Weijun Wang, Pingqiang Cai   +14 more
wiley   +1 more source

L-Alanine: 4,5-dioxovalerate transaminase in Leishmania donovani that differs from mammalian enzyme

, 1995
Leishmania protozoans are the causative agents of leishmaniasis, a major parasitic disease in humans. The parasites manifest a nutritional requirement for heme compounds since they are deficient in heme biosynthesis.
Bhatnagar, Rakesh, Kasturi Datta, Poonam Salotra, Rakesh Bhatnagar, Sagar, Richa, Richa Sagar, Salotra, Poonam, Datta, Kasturi   +7 more
core   +1 more source

Microenvironment‐Responsive Nanomedicine Enables Vertical Modulation of Mitochondrial Pathological Networks in Myocardial Ischemia–Reperfusion Injury

Advanced Science, EarlyView.
A mitochondria‐targeted, microenvironment‐responsive nanoplatform enables pH/ROS‐triggered co‐delivery of berberine and isoliensinine to orchestrate ROS scavenging, inflammation suppression, and apoptosis inhibition. This vertical modulation of mitochondrial pathological networks preserves mitochondrial function and effectively mitigates myocardial ...
Jue Wang, Jia Zhou, Wenqin Yuan, Tianjiao Zhao, Yunying Huang, Yingci Xia, Yuting Lin, Fei Li, Qiong Huang, Chong Liu, Kelong Ai, Qun Qin   +11 more
wiley   +1 more source

Evaluation of elevated serum liver enzymes and metabolic syndrome in the PERSIAN Guilan cohort study population

Heliyon
Objective: The purpose of this study is to evaluate the association between elevated serum liver enzymes and Metabolic Syndrome (MetS) in Prospective Epidemiological Research Studies of the Iranian Adults (PERSIAN) Guilan Cohort Study (PGCS) population ...
Saideh Ghotbi, Farahnaz Joukar, Mahdi Orang Goorabzarmakhi, Milad Shahdkar, Saman Maroufizadeh, Kourosh Mojtahedi, Mehrnaz Asgharnezhad, Mohammadreza Naghipour, Fariborz Mansour-Ghanaei   +8 more
doaj   +1 more source

EFFECT OF MONENSIN, AN IONOPHORE ANTIBIOTIC ON SERUM BIOCHEMICAL PROFILE IN BROILER CHICKEN [PDF]

Journal of Veterinary and Animal Sciences, 1999
Monensin, an ionophore antibiotic fed to broiler chicken at the rate of 121 (recommended use level), 363 and 726 ppm produced a significant and dose dependent increase in the activity of serum aspartate transaminase (AST), alanine transaminase (ALT ...
A. Prasad, U. Venkateswarlu, P. Ravi Kumar   +2 more
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