Results 81 to 90 of about 276,470 (294)

Scheme of the net reaction catalyzed by alanine transaminase (glutamic acid-pyruvic acid transaminase, GPT).

, 2014
In the first half-reaction (1) L-alanine is converted to pyruvate with the concomitant conversion of the Lys-PLP Schiff-base linked cofactor to free Lys and PMP (in AlaA, the catalytic lysine residue is Lys240).
Miguel López-Estepa (596818), Kenneth E. Rudd (13378), Andrew J. Richardson (596820), M. Cristina Vega (123208), Juan F. Quintana (525369), Francisco J. Fernandez (5655238), Miquel Coll (411730), Fernando Garces (596819), Esther Peña-Soler (596817)   +8 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Affinity purification and properties of rat liver mitochondrial L-alanine:4,5-dioxovalerate transaminase and its inhibition by hemin

, 1986
The present study describes a new rapid procedure for purification of L-alanine:4,5-dioxovalerate transaminase from rat liver mitochondria which was purified 243-fold with a 32% yield to apparent homogeneity. The purification procedure involved protamine
Shanker, J., Datta, K.
core   +2 more sources

ROS Self‐Supply Nanoplatform Based on Fenton Catalyst for Chemodynamic and Immunotherapy: Reprogramming Cold Tumor Into Hot Tumor in Cancer Treatment

Advanced Science, EarlyView.
A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee, Jack Chun Hin Chen, Wai Wing Cheng, Kwan Yee Lau, Hiu Yee Kwan, Ngar‐Yun Ellen Poon, Hung‐Wing Li   +6 more
wiley   +1 more source

In Situ Genetic Engineering Facilitates MMP‐9‐Responsive TIMP1 Release Through Proteolytic Cleavage to Boost Diabetic Wound Healing

Advanced Science, EarlyView.
This study develops an MMP‐9‐responsive protein release system that transforms resident cells into drug depots through in situ genetic engineering. Anchored to the membrane, the therapeutic protein TIMP1 is selectively released upon MMP‐9 cleavage.
Yuan Zhang, Jiani Deng, Man Yee Cheung, Tingting Fu, Xufeng Qi, Dongqing Cai, Jianmin Sun, Gang Lu, Peng Shi, Wai‐Yee Chan, Xu Li, Hui Zhao   +11 more
wiley   +1 more source

In vitro translocation of L-alanine: 4,5-dioxovalerate transaminase into rat kidney mitochondria

, 1993
A specific rabbit antibody was prepared against rat kidney mitochondrial L-alanine: 4,5-dioxovalerate transaminase, which is one of the two enzymes catalyzing the synthesis of (δ-aminolevulinic acid in the heme biosynthetic pathway.
Datta, Kasturi, Tyagi, Rakesh Kumar
core   +2 more sources

Significantly raised alanine aminotransferase level following single dose of intravenous paracetamol in a healthy patient

Indian Journal of Pain, 2015
A 12-year-old ASA I female patient underwent correction of posterior scoliosis of dorsolumbar spine under total intravenous anesthesia using a combination of remifentanil and propofol.
Rashid M Khan, Sujit Nair, Adil Sulaiman Al-Kharusi, Haris Aziz, Naresh Kaul   +4 more
doaj   +1 more source

UC Davis - Alanine transaminase v1 [PDF]

, 2019
Summary: Alanine transaminase (ALT) also known as alanine aminotransferase or (sGPT) is a metabolic enzyme expressed primarily in the liver. Elevation of ALT levels is an indication of liver damage and has been associated with liver injury. ALT levels are monitored routinely in patients with liver diseases.
openaire   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Persistently normal alanine transaminase levels in chronic C hepatitis: What does it tell us?

, 2001
Background/Aims: We evaluated the demographic, clinical, histological and serological characteristics of chronic hepatitis C infection with persistently normal serum alanine transaminase levels and compared the results with those obtained in a group of ...
Dincer, D, Kaymakoglu, S, Demir, K, Turkoglu, S, Okten, A, Bozaci, M, Tuncer, I, Besisik, F, Cevikbas, U, Cakaloglu, Y   +9 more
core