Results 91 to 100 of about 1,366 (166)

Impact of Efavirenz on Heme Protein Induction and Biomarkers: Insights From In Vitro Experiments and a Clinical Study

Clinical and Translational Science, Volume 19, Issue 3, March 2026.
ABSTRACT Coproporphyrin I (CPI) is increasingly recognized as a reliable endogenous biomarker for hepatic OATP1B transporters. However, confounding mechanisms such as increased heme biosynthesis driven by induction of CYP enzymes, which are hemoproteins, may affect CPI levels independently of OATP1B1 inhibition. The aim of this study was to investigate
Leila Potzel, Jonny Kinzi, Isabell Seibert, Markus Grube, Werner Siegmund, Henriette E. Meyer zu Schwabedissen   +5 more
wiley   +1 more source

Identification and Validation of Potential Diagnostic Biomarkers for Pulmonary Arterial Hypertension Based on Gene Expression Profiling

Pulmonary Circulation
Pulmonary arterial hypertension (PAH) is a life‐threatening condition characterized by elevated pulmonary vascular resistance. Despite recent advances, early diagnosis remains challenging due to nonspecific symptoms. By utilizing RNA sequencing (RNA‐seq)
Huan Liu, Mengyu Wu, Guanming Qi, Feifei Ma, Yunshan Cao   +4 more
doaj   +1 more source

Identification of potential diagnostic biomarkers for systemic juvenile idiopathic arthritis by integrative transcriptomic analysis

Autoimmunity
The current diagnostic criteria for systemic juvenile idiopathic arthritis (sJIA) lack specificity. Diagnostic biomarkers are in urgent need to help with the early diagnosis of sJIA. Gene expression data of a JIA cohort study from Gene Expression Omnibus
Jingwei Wang, Xiaochuan Wu, Lanjun Shuai, Yaqian Fu, Tian Shen   +4 more
doaj   +1 more source

Murine erythroid 5‐aminolevulinate synthase: Adenosyl‐binding site Lys221 modulates substrate binding and catalysis

FEBS Open Bio, 2015
5‐Aminolevulinate synthase (ALAS) catalyzes the initial step of mammalian heme biosynthesis, the condensation between glycine and succinyl‐CoA to produce CoA, CO2, and 5‐aminolevulinate. The crystal structure of Rhodobacter capsulatus ALAS indicates that
Bosko M. Stojanovski, Gloria C. Ferreira
doaj   +1 more source

Anti-Correlation between the Dynamics of the Active Site Loop and C-Terminal Tail in Relation to the Homodimer Asymmetry of the Mouse Erythroid 5-Aminolevulinate Synthase

, 2018
Biosynthesis of heme represents a complex process that involves multiple stages controlled by different enzymes. The first of these proteins is a pyridoxal 5′-phosphate (PLP)-dependent homodimeric enzyme, 5-aminolevulinate synthase (ALAS), that ...
Dominique Catena, Gloria C. Ferreira, Min J. Kong, Ferreira, Gloria C., Uversky, Vladimir N., Kong, Min J., Insung Na, Na, Insung, Catena, Dominique, Vladimir N. Uversky   +9 more
core   +1 more source

Onset of X-linked sideroblastic anemia in the fourth decade

Haematologica, 2004
We report the case of a 40-year female who manifested late onset, pyridoxine-refractory X-linked sideroblastic anemia, heterozygous for the first described frameshift ALAS2 mutation, CD506-507 (-C).
E Cortesao, J Vidan, J Pereira, P Goncalves, ML Ribeiro, G Tamagnini   +5 more
doaj  

Validation of whole-blood transcriptome signature during microdose recombinant human erythropoietin (rHuEpo) administration

BMC Genomics, 2017
Background Recombinant human erythropoietin (rHuEpo) can improve human performance and is therefore frequently abused by athletes. As a result, the World Anti-Doping Agency (WADA) introduced the Athlete Biological Passport (ABP) as an indirect method to ...
Guan Wang, Jérôme Durussel, Jonathan Shurlock, Martin Mooses, Noriyuki Fuku, Georgie Bruinvels, Charles Pedlar, Richard Burden, Andrew Murray, Brendan Yee, Anne Keenan, John D. McClure, Pierre-Edouard Sottas, Yannis P. Pitsiladis   +13 more
doaj   +1 more source

The major splice variant of human 5-aminolevulinate synthase-2 contributes significantly to erythroid heme biosynthesis

, 2004
The initial step of the heme biosynthetic pathway in erythroid cells is catalyzed by an erythroid-specific isoform of 5-aminolevulinate synthase-2 (ALAS2).
Cox, T., Sadlon, T., Wise, P., Matthews, C., May, B., Cox, L., Schwarz, Q., Bottomley, S.   +7 more
core   +1 more source

Integrating multi-omics and deep learning to explore the active ingredients and molecular mechanisms of Cinnamomum migao volatile oil in the treatment of coronary heart disease

Frontiers in Pharmacology
BackgroundCoronary heart disease (CHD) is a major cardiovascular disease. Cinnamomum migao volatile oil (CM-VO) is traditionally used for CHD, but its active basis and mechanisms remain unclear.ObjectiveTo clarify the chemical basis and potential anti ...
Xiaomei Zeng, Jiangtao Guo, Jian Xu, Jian Xu, Yongping Zhang, Yongping Zhang, Xiaoting Zhu, Jie Liu, Jie Liu   +8 more
doaj   +1 more source

TNF-α mutation affects the gene expression profiles of patients with multiple trauma

European Journal of Inflammation, 2015
Multiple trauma can induce sepsis and organ failure, even threaten people’s lives. To further study the mechanisms of multiple trauma, we analyzed microarray of GSE5760.
GT Chen, N Han, GF Li, X Li, G Li, YZ Liu, W Wu, Y Wang, YX Chen, GX Sun, ZC Li, QC Li   +11 more
doaj   +1 more source