Results 111 to 120 of about 1,366 (166)

Multi-Omics Deciphers Divergent Mechanisms in Differentially Cardiac-Remodeled Yili Horses Under Conditions of Equivalent Power Output

Animals
Exercise performance is a critical trait for evaluating the economic and breeding value of working and athletic horses, with cardiac structure and function serving as essential physiological determinants of athletic capacity.
Tongliang Wang, Xixi Yang, Wanlu Ren, Jun Meng, Xinkui Yao, Hongzhong Chu, Runchen Yao, Manjun Zhai, Yaqi Zeng   +8 more
doaj   +1 more source

Metabolomics analysis and mRNA/miRNA profiling reveal potential cardiac regulatory mechanisms in Yili racehorses under different training regimens.

PLoS ONE
Yili horses, a versatile breed from Xinjiang, China, are renowned for their racing abilities. However, studies on the links between cardiac morphology, function, and metabolic profiles with performance are limited.
Tongliang Wang, Jun Meng, Xuan Peng, Jinlong Huang, Yunjiang Huang, Xinxin Yuan, Xueyan Li, Xixi Yang, Xiaokang Chang, Yaqi Zeng, Xinkui Yao   +10 more
doaj   +1 more source

The molecular biology and pyridoxine responsiveness of X-linked sideroblastic anaemia

Haematologica, 1998
Pyridoxine-responsive, X-linked sideroblastic anaemia (XLSA) has been shown to be caused by missense mutations in the erythroid-specific ALA synthase gene, ALAS2. These are scattered widely across the part of the gene encoding the catalytic domain and in
A May, DF Bishop
doaj  

Familial-skewed X-chromosome inactivation as a predisposing factor for late-onset X-linked sideroblastic anemia in carrier females.

, 2000
X-linked sideroblastic anemia (XLSA) is caused by mutations in the erythroid-specific 5-aminolevulinic acid synthase (ALAS2) gene. An elderly woman who presented with an acquired sideroblastic anemia is studied.
CAZZOLA, MARIO, Bishop DF, Rosti V, BERGAMASCHI, GAETANO, Cerani P, May A   +5 more
core  

Concomitant a novel ALAS2 mutation and GATA1 mutation in a newborn: a case report and review of the literature.

American journal of blood research, 2014
GATA-1, an X-linked gene, encodes a transcription factor that plays a role in erythropoiesis and megakaryopoiesis. GATA-1 mutations have been associated with various diseases, such as X-linked thrombocytopenia. ALAS2 is an X-linked erythroid-specific isoenzyme expressed during erythropoiesis.
Bhavya S, Doshi, Carlos, Abramowsky, Michael, Briones, Silvia T, Bunting   +3 more
openaire   +1 more source

mRNA Biomarkers in Dried Blood Spots May Improve Detection of Autologous Blood Micro-Transfusions Using an Individualized Approach

Autologous blood transfusions (ABTs) are prohibited by the World Anti-Doping Agency (WADA), yet detecting autologous blood micro-transfusions (ABMTs) remains a challenge.
Bejder, Jacob, Loria, Francesco, Nordsborg, Nikolai B, Oliveira, Jessica Almeida, Andersen, Andreas Breenfeldt, Salamin, Olivier, Kuuranne, Tiia, Leuenberger, Nicolas   +7 more
core   +1 more source

mRNA biomarkers sensitive and specific to micro-dose erythropoietin treatment at sea level and altitude

Recombinant human erythropoietin (rhEPO) is prohibited by the World Anti-Doping Agency. rhEPO abuse can be indirectly detected via the athlete biological passport (ABP). However, altitude exposure challenges interpretation of the ABP.
Baastrup Nordsborg, Nikolai, Leuenberger, N., Grabherr, Silke, Loria, Francesco, Breenfeldt Andersen, Andreas, Kuuranne, T., Bonne, T., Bejder, J., Grabherr, S., Bonne, Thomas, Loria, F., Bejder, Jacob, Baastrup Nordsborg, N., Kuuranne, Tiia, Breenfeldt Andersen, A., Leuenberger, Nicolas   +15 more
core   +1 more source

The Molecular Basis Underlying Heme Biosynthesis Dysfunction and Disease Originating from C-Terminal Mutations in Aminolevulinic Acid Synthase

Aminolevulinic acid synthase (ALAS) is a conserved heme biosynthetic enzyme that catalyzes the first, rate-limiting step of heme biosynthesis in non-plant eukaryotes and alphaproteobacteria.
Taylor, Jessica
core  

Iron Regulatory Protein-1 Protects against Mitoferrin-1-deficient Porphyria.

, 2014
Mitochondrial iron is essential for the biosynthesis of heme and iron-sulfur ([Fe-S]) clusters in mammalian cells. In developing erythrocytes, iron is imported into the mitochondria by MFRN1 (mitoferrin-1, SLC25A37).
Eisenstein, Richard S, Peters, Luanne L, Chen, Michael J, Langer, Nathaniel B, Kaplan, Jerry, Gwynn, Babette, Wittig, Johannes G, Hentze, Matthias W, Ward, Diane M, Anderson, Sheila A, Shaw, George C, Huston, Nicholas C, Datta, Sumon, Chung, Jacky, Lambert, Amy J, Paradkar, Prasad N, Schlaeger, Thorsten M, Sahr, Kenneth, Boyer, Leah F, Li, Liangtao, Deck, Kathryn M, Wei, Zong, Chen, Wen, Galy, Bruno, Lu, Wange, Paw, Barry H   +25 more
core  

Growth hormone increases ALAS2, the rate-limiting enzyme of Hbb in male rat hippocampus [PDF]

Endocrine Abstracts, 2016
Marion Walser, Jan Oscarsson, Ruth Wickelgren, Jorgen Isgaard, David AEberg   +4 more
openaire   +1 more source